White Matter Injury After Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) accounts for 15% of all stroke cases. ICH is a devastating form of stroke associated with high morbidity, mortality, and disability. Preclinical studies have explored the mechanisms of neuronal death and gray matter damage after ICH. However, few studies ha...
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2021-06-01
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doaj-7c37a08b4a2144d19a413ac0b3ddca822021-06-10T07:22:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-06-011210.3389/fneur.2021.562090562090White Matter Injury After Intracerebral HemorrhageXiongjie FuGuoyang ZhouJianfeng ZhuangChaoran XuHang ZhouYucong PengYang CaoHanhai ZengJianru LiFeng YanLin WangGao ChenSpontaneous intracerebral hemorrhage (ICH) accounts for 15% of all stroke cases. ICH is a devastating form of stroke associated with high morbidity, mortality, and disability. Preclinical studies have explored the mechanisms of neuronal death and gray matter damage after ICH. However, few studies have examined the development of white matter injury (WMI) following ICH. Research on WMI indicates that its pathophysiological presentation involves axonal damage, demyelination, and mature oligodendrocyte loss. However, the detailed relationship and mechanism between WMI and ICH remain unclear. Studies of other acute brain insults have indicated that WMI is strongly correlated with cognitive deficits, neurological deficits, and depression. The degree of WMI determines the short- and long-term prognosis of patients with ICH. This review demonstrates the structure and functions of the white matter in the healthy brain and discusses the pathophysiological mechanism of WMI following ICH. Our review reveals that the development of WMI after ICH is complex; therefore, comprehensive treatment is essential. Understanding the relationship between WMI and other brain cells may reveal therapeutic targets for the treatment of ICH.https://www.frontiersin.org/articles/10.3389/fneur.2021.562090/fullspontaneous intracerebral hemorrhagewhite matter injurydemyelinationaxonal damagestroke |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiongjie Fu Guoyang Zhou Jianfeng Zhuang Chaoran Xu Hang Zhou Yucong Peng Yang Cao Hanhai Zeng Jianru Li Feng Yan Lin Wang Gao Chen |
spellingShingle |
Xiongjie Fu Guoyang Zhou Jianfeng Zhuang Chaoran Xu Hang Zhou Yucong Peng Yang Cao Hanhai Zeng Jianru Li Feng Yan Lin Wang Gao Chen White Matter Injury After Intracerebral Hemorrhage Frontiers in Neurology spontaneous intracerebral hemorrhage white matter injury demyelination axonal damage stroke |
author_facet |
Xiongjie Fu Guoyang Zhou Jianfeng Zhuang Chaoran Xu Hang Zhou Yucong Peng Yang Cao Hanhai Zeng Jianru Li Feng Yan Lin Wang Gao Chen |
author_sort |
Xiongjie Fu |
title |
White Matter Injury After Intracerebral Hemorrhage |
title_short |
White Matter Injury After Intracerebral Hemorrhage |
title_full |
White Matter Injury After Intracerebral Hemorrhage |
title_fullStr |
White Matter Injury After Intracerebral Hemorrhage |
title_full_unstemmed |
White Matter Injury After Intracerebral Hemorrhage |
title_sort |
white matter injury after intracerebral hemorrhage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-06-01 |
description |
Spontaneous intracerebral hemorrhage (ICH) accounts for 15% of all stroke cases. ICH is a devastating form of stroke associated with high morbidity, mortality, and disability. Preclinical studies have explored the mechanisms of neuronal death and gray matter damage after ICH. However, few studies have examined the development of white matter injury (WMI) following ICH. Research on WMI indicates that its pathophysiological presentation involves axonal damage, demyelination, and mature oligodendrocyte loss. However, the detailed relationship and mechanism between WMI and ICH remain unclear. Studies of other acute brain insults have indicated that WMI is strongly correlated with cognitive deficits, neurological deficits, and depression. The degree of WMI determines the short- and long-term prognosis of patients with ICH. This review demonstrates the structure and functions of the white matter in the healthy brain and discusses the pathophysiological mechanism of WMI following ICH. Our review reveals that the development of WMI after ICH is complex; therefore, comprehensive treatment is essential. Understanding the relationship between WMI and other brain cells may reveal therapeutic targets for the treatment of ICH. |
topic |
spontaneous intracerebral hemorrhage white matter injury demyelination axonal damage stroke |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.562090/full |
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