X-linked juvenile retinoschisis: phenotypic and genetic characterization

• Main Authors: Rasa Strupaitė, Laima Ambrozaitytė, Loreta Cimbalistienė, Rimvydas Ašoklis, Algirdas Utkus
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2018-11-01
• Series: International Journal of Ophthalmology
• Subjects: X-linked retinoschisis; RS1 mutation; optical coherence tomography; electroretinogram
• Online Access: http://www.ijo.cn/en_publish/2018/11/20181122.pdf
• ISSN: 2222-3959; 2227-4898

Juvenile X-linked retinoschisis (XLRS, MIM#312700) belongs to a group of the vitreoretinal dystrophies. We aimed to describe the phenotype-genotype correlation of three XLRS cases in juveniles with different novel mutations from the Lithuanian population. The patients demonstrated macular retinoschisis and typical cyst-like cavities on spectral-domain optical coherence tomography (SD-OCT) images. The mean central foveal thickness was 569.7 µm. Two patients presented with peripheral retinoschisis. Flash electroretinogram demonstrated a reduced b/a ratio (<1.0) in all patients. RS1 (NM_000330.3) gene coding exons Sanger sequencing was performed. RS1 c.599G>T (p.R200L) mutation was detected in one case, showing to be pathogenic in silico analysis. c. (92_97) insC (p.W33fs) mutation was identified for another patient, indicating the variant is possibly damaging in silico analysis. The third case was identified with a pathogenic mutation c.422C>G (p.R141H), HGMD CM981753. These are the first cases of XLRS in the Lithuanian population confirmed by molecular genotyping. Presented patients had a different genotype but similar phenotypic traits.