Nucleostemin: A new trailblazer in oral squamous cell carcinoma – A brief review

Nucleostemin: A new trailblazer in oral squamous cell carcinoma – A brief review

Nucleostemin (NS) is a guanine nucleotide binding protein like 3 (GNLP 3) found in the nucleolus in neuroepithelial stem cells, embryonic stem cells and in cancer stem cells. It is observed to be an initiator for uncontrolled cellular proliferation that is responsible for cancer progression by inter...

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Bibliographic Details
Main Authors: Sayani Shome, Rudra Prasad Chatterjee, Sanchita Kundu, Sanjeet Kumar Das
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Indian Journal of Dental Sciences
Subjects:
cell cycle
malignant transformation
nucleostemin
p53
Online Access:http://www.ijds.in/article.asp?issn=0976-4003;year=2020;volume=12;issue=2;spage=113;epage=115;aulast=Shome
Description
Summary:Nucleostemin (NS) is a guanine nucleotide binding protein like 3 (GNLP 3) found in the nucleolus in neuroepithelial stem cells, embryonic stem cells and in cancer stem cells. It is observed to be an initiator for uncontrolled cellular proliferation that is responsible for cancer progression by interaction with p53, mouse double minute 2 (MDM2) and cell-cycle.
ISSN:0976-4003
2231-2293

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