ANTIOXIDANT AND PRO-OXIDANT EFFECT OF ASCORBIC ACID

• Main Authors: Goran Rankovic, Snezana Cekic, Voja Pavlovic, Nenad Stoiljkovic
• Format: Article
• Language: English
• Published: University in Nis, Faculty of Medicine 2005-01-01
• Series: Acta Medica Medianae
• Subjects: ascorbic acid; vitamin E; free radicals; lipid per-oxidation
• Online Access: http://publisher.medfak.ni.ac.rs/2005-html/1-broj/11-rad/11-ANTIOXIDANT%20AND%20PRO-OXIDANT%20EFFECT%20OF%20ASCORBIC%20ACID.pdf

Free radicals attack proteins, lipids, enzymes and DNA causing pathological changes in organism. There are many mechanisms that organism uses to fight against free radicals. Ascorbic acid is one of the strongest reducers and eliminators of free radicals. It reduces stable oxygenic, azoth and thyol radicals and acts as a primary defense against water radicals in blood. When radicals are dissolved in water suspensions of erythrocytes and low density lipoproteins (LDL), ascorbic acid catches and eliminates free radicals before they arrive to the membrane and LDL molecules. Even though ascorbic acid is not capable of eliminating free radicals out of fluid medium, it acts as synergist to alpha-tocopherol in lipid section, contributes to the lessening of lipid tocoperoxil radicals, and above all, regenerates alpha-tocopherol. Ascorbic acid may act as pro-oxidant under in vitro conditions in the presence of metals; however, this effect is probably not important under in vivo conditions where metal ions, being sequestered, become second reducers.