Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam

Objectives: Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. Methods: A cross-sectional study...

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Main Authors: Le Anh Tuan, MD, PhD, Kiesha Prem, PhD, Quang Duy Pham, MD, PhD, Zheng Quan Toh, PhD, Hau Phuc Tran, MD, PhD, Phuc Duy Nguyen, MSc, Chu Thi Ngoc Mai, BSc, Le Thi Khanh Ly, BSc, Van Cao, PhD, Tam-Duong Le-Ha, PhD, Nguyen Anh Tuan, PhD, Mark Jit, PhD, Kathryn Bright, BN, Marc Brisson, PhD, Thuong Vu Nguyen, MD, PhD, Suzanne Garland, MD, PhD, Dang Duc Anh, PhD, Nguyen Van Trang, PhD, Kim Mulholland, MD, PhD
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:International Journal of Infectious Diseases
Subjects:
MSM
HPV
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971221007189
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spelling doaj-7c472cfe37d045a2b7ec4bcd81da615c2021-10-11T04:15:37ZengElsevierInternational Journal of Infectious Diseases1201-97122021-11-01112136143Anal human papillomavirus prevalence and risk factors among men who have sex with men in VietnamLe Anh Tuan, MD, PhD0Kiesha Prem, PhD1Quang Duy Pham, MD, PhD2Zheng Quan Toh, PhD3Hau Phuc Tran, MD, PhD4Phuc Duy Nguyen, MSc5Chu Thi Ngoc Mai, BSc6Le Thi Khanh Ly, BSc7Van Cao, PhD8Tam-Duong Le-Ha, PhD9Nguyen Anh Tuan, PhD10Mark Jit, PhD11Kathryn Bright, BN12Marc Brisson, PhD13Thuong Vu Nguyen, MD, PhD14Suzanne Garland, MD, PhD15Dang Duc Anh, PhD16Nguyen Van Trang, PhD17Kim Mulholland, MD, PhD18National Institute of Hygiene and Epidemiology, Hanoi, VietnamLondon School of Hygiene and Tropical Medicine, London, UKPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamInfection and Immunity, Murdoch Children's Research Institute, VIC, Australia; Department of Paediatrics, The University of Melbourne, VIC, AustraliaPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamNational Institute of Hygiene and Epidemiology, Hanoi, VietnamNational Institute of Hygiene and Epidemiology, Hanoi, VietnamPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamNational Institute of Hygiene and Epidemiology, Hanoi, VietnamLondon School of Hygiene and Tropical Medicine, London, UK; School of Public Health, University of Hong Kong, Hong Kong, SAR, China; Public Health England, Modelling and Economics Unit, London, UKInfection and Immunity, Murdoch Children's Research Institute, VIC, AustraliaCentre de recherche du CHU de Québec, Université Laval, Québec, QC, Canada; Department of Social and Preventive Medicine, Université Laval, Québec, CanadaPasteur Institute in Ho Chi Minh City, Ho Chi Minh City, VietnamInfection and Immunity, Murdoch Children's Research Institute, VIC, Australia; Centre for Women's Infectious Diseases, The Royal Women's Hospital, Melbourne, Department of Obstetrics and Gynaecology, University of Melbourne, AustraliaNational Institute of Hygiene and Epidemiology, Hanoi, VietnamNational Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Corresponding author.London School of Hygiene and Tropical Medicine, London, UK; Infection and Immunity, Murdoch Children's Research Institute, VIC, Australia; Department of Paediatrics, The University of Melbourne, VIC, AustraliaObjectives: Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. Methods: A cross-sectional study of 799 MSM aged 16-50 years was conducted in Vietnam in 2017-2018. Information was collected on risk behaviours, and knowledge of HPV and anal cancer; rectal swabs were taken to detect anal HPV infection. An in-house polymerase chain reaction and Genoflow HPV array test kit were used for HPV detection and genotyping. Results: The median age of the study participants was 25 years (range 18-52). Overall prevalence of any HPV and HPV16/18 infection was 32.3% and 11.0%, respectively. A higher prevalence of high-risk HPV infection to all 14 types tested was found in Ho Chi Minh City (30.9%) than in Hanoi (18.4%). High-risk HPV infection was associated with inconsistent condom use and history of engaging in sex under the influence of drugs (adjusted odds ratio (aOR), 2.27; 95% CI, 1.48-10.67), as well as having multiple sexual partners (aOR, 1.01; 95% CI, 1.00–1.02). Conclusions: High-risk anal HPV infections in Vietnamese MSM were significantly associated with risky sexual behaviours. A targeted HPV vaccination strategy would have substantial benefit for MSM in Vietnam.http://www.sciencedirect.com/science/article/pii/S1201971221007189Men who have sex with menMSMHPVRisk factorsVietnam
collection DOAJ
language English
format Article
sources DOAJ
author Le Anh Tuan, MD, PhD
Kiesha Prem, PhD
Quang Duy Pham, MD, PhD
Zheng Quan Toh, PhD
Hau Phuc Tran, MD, PhD
Phuc Duy Nguyen, MSc
Chu Thi Ngoc Mai, BSc
Le Thi Khanh Ly, BSc
Van Cao, PhD
Tam-Duong Le-Ha, PhD
Nguyen Anh Tuan, PhD
Mark Jit, PhD
Kathryn Bright, BN
Marc Brisson, PhD
Thuong Vu Nguyen, MD, PhD
Suzanne Garland, MD, PhD
Dang Duc Anh, PhD
Nguyen Van Trang, PhD
Kim Mulholland, MD, PhD
spellingShingle Le Anh Tuan, MD, PhD
Kiesha Prem, PhD
Quang Duy Pham, MD, PhD
Zheng Quan Toh, PhD
Hau Phuc Tran, MD, PhD
Phuc Duy Nguyen, MSc
Chu Thi Ngoc Mai, BSc
Le Thi Khanh Ly, BSc
Van Cao, PhD
Tam-Duong Le-Ha, PhD
Nguyen Anh Tuan, PhD
Mark Jit, PhD
Kathryn Bright, BN
Marc Brisson, PhD
Thuong Vu Nguyen, MD, PhD
Suzanne Garland, MD, PhD
Dang Duc Anh, PhD
Nguyen Van Trang, PhD
Kim Mulholland, MD, PhD
Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
International Journal of Infectious Diseases
Men who have sex with men
MSM
HPV
Risk factors
Vietnam
author_facet Le Anh Tuan, MD, PhD
Kiesha Prem, PhD
Quang Duy Pham, MD, PhD
Zheng Quan Toh, PhD
Hau Phuc Tran, MD, PhD
Phuc Duy Nguyen, MSc
Chu Thi Ngoc Mai, BSc
Le Thi Khanh Ly, BSc
Van Cao, PhD
Tam-Duong Le-Ha, PhD
Nguyen Anh Tuan, PhD
Mark Jit, PhD
Kathryn Bright, BN
Marc Brisson, PhD
Thuong Vu Nguyen, MD, PhD
Suzanne Garland, MD, PhD
Dang Duc Anh, PhD
Nguyen Van Trang, PhD
Kim Mulholland, MD, PhD
author_sort Le Anh Tuan, MD, PhD
title Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
title_short Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
title_full Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
title_fullStr Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
title_full_unstemmed Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam
title_sort anal human papillomavirus prevalence and risk factors among men who have sex with men in vietnam
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2021-11-01
description Objectives: Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population. Methods: A cross-sectional study of 799 MSM aged 16-50 years was conducted in Vietnam in 2017-2018. Information was collected on risk behaviours, and knowledge of HPV and anal cancer; rectal swabs were taken to detect anal HPV infection. An in-house polymerase chain reaction and Genoflow HPV array test kit were used for HPV detection and genotyping. Results: The median age of the study participants was 25 years (range 18-52). Overall prevalence of any HPV and HPV16/18 infection was 32.3% and 11.0%, respectively. A higher prevalence of high-risk HPV infection to all 14 types tested was found in Ho Chi Minh City (30.9%) than in Hanoi (18.4%). High-risk HPV infection was associated with inconsistent condom use and history of engaging in sex under the influence of drugs (adjusted odds ratio (aOR), 2.27; 95% CI, 1.48-10.67), as well as having multiple sexual partners (aOR, 1.01; 95% CI, 1.00–1.02). Conclusions: High-risk anal HPV infections in Vietnamese MSM were significantly associated with risky sexual behaviours. A targeted HPV vaccination strategy would have substantial benefit for MSM in Vietnam.
topic Men who have sex with men
MSM
HPV
Risk factors
Vietnam
url http://www.sciencedirect.com/science/article/pii/S1201971221007189
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