Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates

Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates

Matrix Gla protein (Mgp) and bone Gla protein (Bgp) are vitamin-K dependent proteins that bind calcium in their γ-carboxylated versions in mammals. They are recognized as positive (Bgp) or negative (Mgp and Bgp) regulators of biomineralization in a number of tissues, including skeletal tissues of bo...

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Bibliographic Details
Main Authors: Nicolas Leurs, Camille Martinand-Mari, Stéphanie Ventéo, Tatjana Haitina, Mélanie Debiais-Thibaud
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
Gla protein
osteocalcin
shark
skeleton
evo-devo
biomineralization
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.620659/full

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