Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14807 |
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doaj-7c48b88ebe1f45628a4d604983c1bc112021-05-11T07:31:02ZengNature Publishing GroupNature Communications2041-17232017-04-018111410.1038/ncomms14807Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wallXiaoping Liu0Mohamed A. El-Mahdy1James Boslett2Saradhadevi Varadharaj3Craig Hemann4Tamer M. Abdelghany5Raed S. Ismail6Sean C. Little7Danlei Zhou8Le Thi Thanh Thuy9Norifumi Kawada10Jay L. Zweier11Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityDepartment of Hepatology, Graduate School of Medicine, Osaka City UniversityDepartment of Hepatology, Graduate School of Medicine, Osaka City UniversityDavis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State UniversityThe gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension.https://doi.org/10.1038/ncomms14807 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier |
| spellingShingle |
Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall Nature Communications |
| author_facet |
Xiaoping Liu Mohamed A. El-Mahdy James Boslett Saradhadevi Varadharaj Craig Hemann Tamer M. Abdelghany Raed S. Ismail Sean C. Little Danlei Zhou Le Thi Thanh Thuy Norifumi Kawada Jay L. Zweier |
| author_sort |
Xiaoping Liu |
| title |
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| title_short |
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| title_full |
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| title_fullStr |
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| title_full_unstemmed |
Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| title_sort |
cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive to angiotensin-mediated hypertension. |
| url |
https://doi.org/10.1038/ncomms14807 |
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