Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism
Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differenti...
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doaj-7c4b5dce26754bc78e9e847c935c3d762020-11-24T23:26:30ZengElsevierAsian Journal of Surgery1015-95842007-10-0130428628910.1016/S1015-9584(08)60041-XLarge Retrosternal Parathyroid Carcinoma with Primary HyperparathyroidismGeok Chin Tan0M. Sidik Shiran1Manickam Swaminathan2K. Seng Phang3Muhammad Rohaizak4Department of Pathology, Kuala Lumpur, MalaysiaDepartment of Pathology, Universiti Putra Malaysia, Kuala Lumpur, MalaysiaDepartment of Pathology, Kuala Lumpur, MalaysiaDepartment of Pathology, Kuala Lumpur, MalaysiaDepartment of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaParathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective treatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathyroid carcinomas is quite variable; 5-year survival rates vary from 40% to 86%, while the 10-year survival rate is approximately 49%. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia.http://www.sciencedirect.com/science/article/pii/S101595840860041Xcarcinomaendocrinehypercalcaemiahyperparathyroidismparathyroid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geok Chin Tan M. Sidik Shiran Manickam Swaminathan K. Seng Phang Muhammad Rohaizak |
spellingShingle |
Geok Chin Tan M. Sidik Shiran Manickam Swaminathan K. Seng Phang Muhammad Rohaizak Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism Asian Journal of Surgery carcinoma endocrine hypercalcaemia hyperparathyroidism parathyroid |
author_facet |
Geok Chin Tan M. Sidik Shiran Manickam Swaminathan K. Seng Phang Muhammad Rohaizak |
author_sort |
Geok Chin Tan |
title |
Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism |
title_short |
Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism |
title_full |
Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism |
title_fullStr |
Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism |
title_full_unstemmed |
Large Retrosternal Parathyroid Carcinoma with Primary Hyperparathyroidism |
title_sort |
large retrosternal parathyroid carcinoma with primary hyperparathyroidism |
publisher |
Elsevier |
series |
Asian Journal of Surgery |
issn |
1015-9584 |
publishDate |
2007-10-01 |
description |
Parathyroid carcinoma is an uncommon cause of parathyroid hormone (PTH)-dependent hypercalcaemia, accounting for less than 1% of all cases of hyperparathyroidism. Parathyroid carcinoma is an indolent tumour with rather low malignant potential. Consideration of parathyroid carcinoma in the differential diagnosis of hypercalcaemic disorders is important because the morbidity and mortality are substantial and the best prognosis is associated with early recognition and surgical resection. Clinical indicators favouring parathyroid carcinoma over benign disease include markedly raised serum calcium levels, PTH and alkaline phosphatase. A palpable neck mass with both kidney and skeletal manifestations also give a high index of suspicion of parathyroid carcinoma. Histopathology alone is not sufficient to diagnose parathyroid cancer; it has to be correlated with the clinical findings. The initial and most effective treatment for parathyroid carcinoma is complete resection of the primary lesion, and repeated operations for recurrence are useful. The prognosis of parathyroid carcinomas is quite variable; 5-year survival rates vary from 40% to 86%, while the 10-year survival rate is approximately 49%. We report a case of parathyroid carcinoma occurring in a 55-year-old woman who presented with bone pain and hypercalcaemia. |
topic |
carcinoma endocrine hypercalcaemia hyperparathyroidism parathyroid |
url |
http://www.sciencedirect.com/science/article/pii/S101595840860041X |
work_keys_str_mv |
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