Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimers disease

• Main Authors: Xiaonan Wang, Xihai Li, Jie Yang, Ming Yu, Jinmei Wu
• Format: Article
• Language: English
• Published: Bangladesh Pharmacological Society 2016-03-01
• Series: Bangladesh Journal of Pharmacology
• Subjects: Alzheimers disease; Amyloid precursor protein; Granulocyte
• Online Access: https://www.banglajol.info/index.php/BJP/article/view/26412

The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimers disease. Immunohistochemistry and flow cytometry were used to evaluate amyloid precursor protein expression levels and subcellular localization in Alzheimers disease. Much higher amyloid precursor protein expression was observed in some leukocytes from Alzheimers disease patients, compared with samples from non-Alzheimers disease controls. In addition, flow cytometry data indicated significantly higher amyloid precursor protein  expression in granulocytes from Alzheimers disease patients compared with control values. No statistically significant differences in amyloid precursor protein  expression were obtained in lymphocytes or monocytes between the patient groups. In conclusion, amyloid precursor protein expression level in peripheral blood granulocyte is a potential biomarker for early diagnosis of Alzheimers disease.