The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats
Objective: To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats. Methods: Sprague-Dawley rats were randomly divided into two groups (n = 6), a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body...
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doaj-7c614448695f47258d698a058ca542e82021-04-02T05:55:21ZengElsevierJournal of Traditional Chinese Medical Sciences2095-75482017-10-014436637110.1016/j.jtcms.2017.12.009The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in ratsGangyan YuLi TanYutao XueMengdi ZhaoYang LuObjective: To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats. Methods: Sprague-Dawley rats were randomly divided into two groups (n = 6), a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body weight) by gavage, and an aspirin group that received aspirin (10 mg/kg body weight) by gavage. The concentration of salicylic acid, an important metabolite of aspirin, was determined by high-performance liquid chromatography in supernatant from blood obtained from the orbital sinus at various time points to examine the effect of TGSL on aspirin. Results: The results showed that the Tmax of salicylic acid was [0.92 (0.58)] hours in the aspirin group and [2.50 (1.22)] hours in the combined group, and was statistically significantly different between the groups (p < .05). Conclusions: TGSL can affect the pharmacokinetics of aspirin at Tmax in rats.http://www.sciencedirect.com/science/article/pii/S2095754817300996AspirinTotal ginsenoside of ginseng stems and leaves (TGSL)Pharmacokinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gangyan Yu Li Tan Yutao Xue Mengdi Zhao Yang Lu |
spellingShingle |
Gangyan Yu Li Tan Yutao Xue Mengdi Zhao Yang Lu The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats Journal of Traditional Chinese Medical Sciences Aspirin Total ginsenoside of ginseng stems and leaves (TGSL) Pharmacokinetics |
author_facet |
Gangyan Yu Li Tan Yutao Xue Mengdi Zhao Yang Lu |
author_sort |
Gangyan Yu |
title |
The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
title_short |
The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
title_full |
The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
title_fullStr |
The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
title_full_unstemmed |
The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
title_sort |
pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats |
publisher |
Elsevier |
series |
Journal of Traditional Chinese Medical Sciences |
issn |
2095-7548 |
publishDate |
2017-10-01 |
description |
Objective: To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats.
Methods: Sprague-Dawley rats were randomly divided into two groups (n = 6), a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body weight) by gavage, and an aspirin group that received aspirin (10 mg/kg body weight) by gavage. The concentration of salicylic acid, an important metabolite of aspirin, was determined by high-performance liquid chromatography in supernatant from blood obtained from the orbital sinus at various time points to examine the effect of TGSL on aspirin.
Results: The results showed that the Tmax of salicylic acid was [0.92 (0.58)] hours in the aspirin group and [2.50 (1.22)] hours in the combined group, and was statistically significantly different between the groups (p < .05).
Conclusions: TGSL can affect the pharmacokinetics of aspirin at Tmax in rats. |
topic |
Aspirin Total ginsenoside of ginseng stems and leaves (TGSL) Pharmacokinetics |
url |
http://www.sciencedirect.com/science/article/pii/S2095754817300996 |
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