Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study
BACKGROUND: Thyroid carcinomas represent the most frequent endocrine malignancies. Recent studies were able to distinguish malignant from benign nodules of the thyroid gland with diffusion-weighted imaging (DWI). Although this differentiation is undoubtedly helpful, presurgical discrimination betwee...
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Series: | Translational Oncology |
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doaj-7c65cd9d08b64fa48b721776a59f75022020-11-24T22:59:41ZengElsevierTranslational Oncology1936-52331944-71242016-10-019540341010.1016/j.tranon.2016.09.001Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary StudyStefan Schob0Peter Voigt1Lionel Bure2Hans-Jonas Meyer3Claudia Wickenhauser4Curd Behrmann5Annekathrin Höhn6Paul Kachel7Henning Dralle8Karl-Titus Hoffmann9Alexey Surov10Department of Neuroradiology, University Leipzig, Leipzig, GermanyDepartment of Diagnostic and Interventional Radiology, University Leipzig, Leipzig, GermanyDepartment of Radiology, McGill University Health Center, Montreal General Hospital, Quebec, CanadaDepartment of Diagnostic Radiology, Martin Luther University Halle-Wittenberg, Leipzig, GermanyDepartment of Pathology, Martin Luther University Halle-Wittenberg, Leipzig, GermanyDepartment of Diagnostic Radiology, Martin Luther University Halle-Wittenberg, Leipzig, GermanyDepartment of Pathology, University Leipzig, Leipzig, GermanyDepartment of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Leipzig, GermanyDepartment of General, Visceral and Vascular Surgery, Martin Luther University Halle-Wittenberg, Leipzig, GermanyDepartment of Neuroradiology, University Leipzig, Leipzig, GermanyDepartment of Diagnostic and Interventional Radiology, University Leipzig, Leipzig, GermanyBACKGROUND: Thyroid carcinomas represent the most frequent endocrine malignancies. Recent studies were able to distinguish malignant from benign nodules of the thyroid gland with diffusion-weighted imaging (DWI). Although this differentiation is undoubtedly helpful, presurgical discrimination between well-differentiated and undifferentiated carcinomas would be crucial to define the optimal treatment algorithm. Therefore, the aim of this study was to investigate if readout-segmented multishot echo planar DWI is able to differentiate between differentiated and undifferentiated subtypes of thyroid carcinomas. PATIENTS AND METHODS: Fourteen patients with different types of thyroid carcinomas who received preoperative DWI were included in our study. In all lesions, apparent diffusion coefficient (ADC)min, ADCmean, ADCmax, and D were estimated on the basis of region of interest measurements after coregistration with T1-weighted, postcontrast images. All tumors were resected and analyzed histopathologically. Ki-67 index, p53 synthesis, cellularity, and total and average nucleic areas were estimated using ImageJ version 1.48. RESULTS: Analysis of variance revealed a statistically significant difference in ADCmean values between differentiated and undifferentiated thyroid carcinomas (P = .022). Spearman Rho calculation identified significant correlations between ADCmax and cell count (r = 0.541, P = .046) as well as between ADCmax and total nuclei area (r = 0.605, P = .022). CONCLUSION: DWI can distinguish between differentiated and undifferentiated thyroid carcinomas.http://www.sciencedirect.com/science/article/pii/S1936523316301425 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefan Schob Peter Voigt Lionel Bure Hans-Jonas Meyer Claudia Wickenhauser Curd Behrmann Annekathrin Höhn Paul Kachel Henning Dralle Karl-Titus Hoffmann Alexey Surov |
spellingShingle |
Stefan Schob Peter Voigt Lionel Bure Hans-Jonas Meyer Claudia Wickenhauser Curd Behrmann Annekathrin Höhn Paul Kachel Henning Dralle Karl-Titus Hoffmann Alexey Surov Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study Translational Oncology |
author_facet |
Stefan Schob Peter Voigt Lionel Bure Hans-Jonas Meyer Claudia Wickenhauser Curd Behrmann Annekathrin Höhn Paul Kachel Henning Dralle Karl-Titus Hoffmann Alexey Surov |
author_sort |
Stefan Schob |
title |
Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study |
title_short |
Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study |
title_full |
Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study |
title_fullStr |
Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study |
title_full_unstemmed |
Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study |
title_sort |
diffusion-weighted imaging using a readout-segmented, multishot epi sequence at 3 t distinguishes between morphologically differentiated and undifferentiated subtypes of thyroid carcinoma—a preliminary study |
publisher |
Elsevier |
series |
Translational Oncology |
issn |
1936-5233 1944-7124 |
publishDate |
2016-10-01 |
description |
BACKGROUND: Thyroid carcinomas represent the most frequent endocrine malignancies. Recent studies were able to distinguish malignant from benign nodules of the thyroid gland with diffusion-weighted imaging (DWI). Although this differentiation is undoubtedly helpful, presurgical discrimination between well-differentiated and undifferentiated carcinomas would be crucial to define the optimal treatment algorithm. Therefore, the aim of this study was to investigate if readout-segmented multishot echo planar DWI is able to differentiate between differentiated and undifferentiated subtypes of thyroid carcinomas. PATIENTS AND METHODS: Fourteen patients with different types of thyroid carcinomas who received preoperative DWI were included in our study. In all lesions, apparent diffusion coefficient (ADC)min, ADCmean, ADCmax, and D were estimated on the basis of region of interest measurements after coregistration with T1-weighted, postcontrast images. All tumors were resected and analyzed histopathologically. Ki-67 index, p53 synthesis, cellularity, and total and average nucleic areas were estimated using ImageJ version 1.48. RESULTS: Analysis of variance revealed a statistically significant difference in ADCmean values between differentiated and undifferentiated thyroid carcinomas (P = .022). Spearman Rho calculation identified significant correlations between ADCmax and cell count (r = 0.541, P = .046) as well as between ADCmax and total nuclei area (r = 0.605, P = .022). CONCLUSION: DWI can distinguish between differentiated and undifferentiated thyroid carcinomas. |
url |
http://www.sciencedirect.com/science/article/pii/S1936523316301425 |
work_keys_str_mv |
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