Altered spontaneous brain activity in obsessive-compulsive personality disorder

Altered spontaneous brain activity in obsessive-compulsive personality disorder

Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patie...

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Main Authors: Hui Lei, Li Huang, Jingxuan Li, Wanting Liu, Jie Fan, Xiaocui Zhang, Jie Xia, Ke Zhao, Xiongzhao Zhu, Hengyi Rao
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Comprehensive Psychiatry
Online Access:http://www.sciencedirect.com/science/article/pii/S0010440X19300677
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spelling doaj-7c65e9ca3e7c4b6b8509a8c9a0b4d51c2020-11-25T00:16:07ZengElsevierComprehensive Psychiatry0010-440X2020-01-0196Altered spontaneous brain activity in obsessive-compulsive personality disorderHui Lei0Li Huang1Jingxuan Li2Wanting Liu3Jie Fan4Xiaocui Zhang5Jie Xia6Ke Zhao7Xiongzhao Zhu8Hengyi Rao9College of Education, Hunan Agricultural University, Changsha, Hunan, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Correspondence to: H. Lei, College of Education, Hunan Agricultural University, Hunan, China.College of Education, Hunan Agricultural University, Changsha, Hunan, ChinaCollege of Education, Hunan Agricultural University, Changsha, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Psychological Institute of Center South University, Changsha, Hunan, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Psychological Institute of Center South University, Changsha, Hunan, ChinaCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Medical Psychological Institute of Center South University, Changsha, Hunan, ChinaLaboratory of Applied Brain and Cognitive Sciences, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Correspondence to: H. Rao, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patients will exhibit altered spontaneous brain activity as compared to healthy controls (HC). Methods: Resting-state fMRI data were acquired in 37 OCPD patients and 37 matched HC. Amplitudes of low-frequency fluctuation (ALFF) were calculated and compared between the two groups. Correlation analysis was performed between regional ALFF values and OCPD severity scores. Results: Significant group differences in regional ALFF were found in multiple brain regions. Compared to HCs, OCPD subjects had increased ALFF in bilateral caudate, left precuneus, left insula, and left medial superior frontal gyrus, and decreased ALFF in the right fusiform gyrus and left lingual gyrus. The ALFF values in the left precuneus correlated with OCPD severity scores. Limitations: We excluded patients with comorbidity and did not conduct cognitive function assessments. Our findings are also limited to cross-sectional analysis. Conclusions: OCPD patients exhibit altered spontaneous neural activity as compared to healthy controls in multiple brain regions, which may reflect different characteristic symptoms of OCPD pathophysiology, including cognitive inflexibility, excessive self-control, lower empathy, and visual attention bias. Keywords: Obsessive-compulsive personality disorder, Resting-state functional MRI, Amplitude of low-frequency fluctuation, Spontaneous neuronal activityhttp://www.sciencedirect.com/science/article/pii/S0010440X19300677
collection DOAJ
language English
format Article
sources DOAJ
author Hui Lei
Li Huang
Jingxuan Li
Wanting Liu
Jie Fan
Xiaocui Zhang
Jie Xia
Ke Zhao
Xiongzhao Zhu
Hengyi Rao
spellingShingle Hui Lei
Li Huang
Jingxuan Li
Wanting Liu
Jie Fan
Xiaocui Zhang
Jie Xia
Ke Zhao
Xiongzhao Zhu
Hengyi Rao
Altered spontaneous brain activity in obsessive-compulsive personality disorder
Comprehensive Psychiatry
author_facet Hui Lei
Li Huang
Jingxuan Li
Wanting Liu
Jie Fan
Xiaocui Zhang
Jie Xia
Ke Zhao
Xiongzhao Zhu
Hengyi Rao
author_sort Hui Lei
title Altered spontaneous brain activity in obsessive-compulsive personality disorder
title_short Altered spontaneous brain activity in obsessive-compulsive personality disorder
title_full Altered spontaneous brain activity in obsessive-compulsive personality disorder
title_fullStr Altered spontaneous brain activity in obsessive-compulsive personality disorder
title_full_unstemmed Altered spontaneous brain activity in obsessive-compulsive personality disorder
title_sort altered spontaneous brain activity in obsessive-compulsive personality disorder
publisher Elsevier
series Comprehensive Psychiatry
issn 0010-440X
publishDate 2020-01-01
description Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patients will exhibit altered spontaneous brain activity as compared to healthy controls (HC). Methods: Resting-state fMRI data were acquired in 37 OCPD patients and 37 matched HC. Amplitudes of low-frequency fluctuation (ALFF) were calculated and compared between the two groups. Correlation analysis was performed between regional ALFF values and OCPD severity scores. Results: Significant group differences in regional ALFF were found in multiple brain regions. Compared to HCs, OCPD subjects had increased ALFF in bilateral caudate, left precuneus, left insula, and left medial superior frontal gyrus, and decreased ALFF in the right fusiform gyrus and left lingual gyrus. The ALFF values in the left precuneus correlated with OCPD severity scores. Limitations: We excluded patients with comorbidity and did not conduct cognitive function assessments. Our findings are also limited to cross-sectional analysis. Conclusions: OCPD patients exhibit altered spontaneous neural activity as compared to healthy controls in multiple brain regions, which may reflect different characteristic symptoms of OCPD pathophysiology, including cognitive inflexibility, excessive self-control, lower empathy, and visual attention bias. Keywords: Obsessive-compulsive personality disorder, Resting-state functional MRI, Amplitude of low-frequency fluctuation, Spontaneous neuronal activity
url http://www.sciencedirect.com/science/article/pii/S0010440X19300677
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