Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia?
Background Since schizophrenia is considered one of the top ten causes of disease-related disability in the world, the development of second-generation (atypical) antipsychotics (SGAs) has increased the hopes of psychiatrists. SGAs, however, cannot be considered a unique pharmacological class since...
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doaj-7c693652109b43e9908eda6fe8f65b032020-11-25T03:55:44ZengSAGE PublishingJournal of Central Nervous System Disease1179-57352011-01-01310.4137/JCNSD.S4138Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia?Chiara Mattei0Maria Paola Rapagnani1Stephen M. Stahl2 Department of Psychiatry, University of Genoa, Genoa, Italy. Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy. Department of Psychiatry, University of Cambridge, Cambridge, UK.Background Since schizophrenia is considered one of the top ten causes of disease-related disability in the world, the development of second-generation (atypical) antipsychotics (SGAs) has increased the hopes of psychiatrists. SGAs, however, cannot be considered a unique pharmacological class since each SGA has many complex pharmacologic actions, only some of which are shared with other SGAs. Even though manyantipsychotics have similar efficacy on average, prescribers may be able to achieve better than average results by considering differences in selecting a specific drug for a specific patient. Clinicians know that each patient is unique. In order to achieve best outcomes for the individual patient, the better therapy is the therapy tailored for the single patient. Objectives With this article, we provide information on a relatively new antipsychotic ziprasidone released in 2001 by Pfizer for the treatment of schizophrenia. Compared with other first line atypical antipsychotics ziprasidone has a unique profile due to potent interaction with serotonergic receptors and lesser action upon α1 adrenergic, H1 and M1 antagonist activities. This paper describes the development of ziprasidone, its unique properties and its metabolically-friendly profile including its receptor binding affinities, pharmacokinetics, CNS activity results of clinical efficacy and relevant clinical trials. Safety, efficacy and patient preference are also examined. The available literature on ziprasidone of the last five years is reviewed.https://doi.org/10.4137/JCNSD.S4138 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chiara Mattei Maria Paola Rapagnani Stephen M. Stahl |
spellingShingle |
Chiara Mattei Maria Paola Rapagnani Stephen M. Stahl Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? Journal of Central Nervous System Disease |
author_facet |
Chiara Mattei Maria Paola Rapagnani Stephen M. Stahl |
author_sort |
Chiara Mattei |
title |
Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? |
title_short |
Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? |
title_full |
Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? |
title_fullStr |
Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? |
title_full_unstemmed |
Ziprasidone Hydrocloride: What Role in the Management of Schizophrenia? |
title_sort |
ziprasidone hydrocloride: what role in the management of schizophrenia? |
publisher |
SAGE Publishing |
series |
Journal of Central Nervous System Disease |
issn |
1179-5735 |
publishDate |
2011-01-01 |
description |
Background Since schizophrenia is considered one of the top ten causes of disease-related disability in the world, the development of second-generation (atypical) antipsychotics (SGAs) has increased the hopes of psychiatrists. SGAs, however, cannot be considered a unique pharmacological class since each SGA has many complex pharmacologic actions, only some of which are shared with other SGAs. Even though manyantipsychotics have similar efficacy on average, prescribers may be able to achieve better than average results by considering differences in selecting a specific drug for a specific patient. Clinicians know that each patient is unique. In order to achieve best outcomes for the individual patient, the better therapy is the therapy tailored for the single patient. Objectives With this article, we provide information on a relatively new antipsychotic ziprasidone released in 2001 by Pfizer for the treatment of schizophrenia. Compared with other first line atypical antipsychotics ziprasidone has a unique profile due to potent interaction with serotonergic receptors and lesser action upon α1 adrenergic, H1 and M1 antagonist activities. This paper describes the development of ziprasidone, its unique properties and its metabolically-friendly profile including its receptor binding affinities, pharmacokinetics, CNS activity results of clinical efficacy and relevant clinical trials. Safety, efficacy and patient preference are also examined. The available literature on ziprasidone of the last five years is reviewed. |
url |
https://doi.org/10.4137/JCNSD.S4138 |
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