Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease

Prion protein oligomers cause neuronal cytoskeletal damage in rapidly progressive Alzheimer’s disease

Abstract Background High-density oligomers of the prion protein (HDPs) have previously been identified in brain tissues of patients with rapidly progressive Alzheimer’s disease (rpAD). The current investigation aims at identifying interacting partners of HDPs in the rpAD brains to unravel the pathol...

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Bibliographic Details
Main Authors: Mohsin Shafiq, Saima Zafar, Neelam Younas, Aneeqa Noor, Berta Puig, Hermann Clemens Altmeppen, Matthias Schmitz, Jakob Matschke, Isidre Ferrer, Markus Glatzel, Inga Zerr
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Neurodegeneration
Subjects:
Rapidly progressive Alzheimer’s disease
rpAD
Growth arrest specific proteins
GAS
Growth arrest specific 2 like 2
G2L2
Online Access:https://doi.org/10.1186/s13024-021-00422-x

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