Imaging of Vulva Syringoma With Reflectance Confocal Microscopy
Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma.Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM....
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2021-02-01
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doaj-7c77a8799b094f2ba1d02679057f4aac2021-02-24T04:43:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-02-01810.3389/fmed.2021.649438649438Imaging of Vulva Syringoma With Reflectance Confocal MicroscopyLin Feng0Yan Lin1Leilei Wang2Hongxiao Chen3Min Gao4Huaxu Liu5Hongyu Yang6Chongqing Hospital of Traditional Chinese Medicine, Chongqing, ChinaShandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaLinyi People's Hospital, Linyi, ChinaShandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaShandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Pathology, St. Vincent Evansville Medical Center, Evansville, IN, United StatesObjectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma.Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation.Results: Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1–2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images.Conclusions: Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma.https://www.frontiersin.org/articles/10.3389/fmed.2021.649438/fullin vivo imagingreflectance confocal microcopyvulvasyringomahistologydifferential diaenosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Feng Yan Lin Leilei Wang Hongxiao Chen Min Gao Huaxu Liu Hongyu Yang |
spellingShingle |
Lin Feng Yan Lin Leilei Wang Hongxiao Chen Min Gao Huaxu Liu Hongyu Yang Imaging of Vulva Syringoma With Reflectance Confocal Microscopy Frontiers in Medicine in vivo imaging reflectance confocal microcopy vulva syringoma histology differential diaenosis |
author_facet |
Lin Feng Yan Lin Leilei Wang Hongxiao Chen Min Gao Huaxu Liu Hongyu Yang |
author_sort |
Lin Feng |
title |
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy |
title_short |
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy |
title_full |
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy |
title_fullStr |
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy |
title_full_unstemmed |
Imaging of Vulva Syringoma With Reflectance Confocal Microscopy |
title_sort |
imaging of vulva syringoma with reflectance confocal microscopy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-02-01 |
description |
Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma.Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation.Results: Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1–2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images.Conclusions: Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma. |
topic |
in vivo imaging reflectance confocal microcopy vulva syringoma histology differential diaenosis |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.649438/full |
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