An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster

An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster

Summary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the...

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Main Authors: Jiejie Sun, Lingling Wang, Chuanyan Yang, Linsheng Song
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300171
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spelling doaj-7c7a5a85680e4c0fade67f29b86c727e2020-11-25T02:11:36ZengElsevieriScience2589-00422020-02-01232An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in OysterJiejie Sun0Lingling Wang1Chuanyan Yang2Linsheng Song3Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, 52 Heishijiao Street, Dalian 116023, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, ChinaLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, 52 Heishijiao Street, Dalian 116023, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China; Dalian Key Laboratory of Aquatic Animal Diseases Prevention and Control, Dalian Ocean University, Dalian 116023, China; Corresponding authorLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, 52 Heishijiao Street, Dalian 116023, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, ChinaLiaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, 52 Heishijiao Street, Dalian 116023, China; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China; Corresponding authorSummary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the downstream response are still not clear in invertebrates. In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. CgIgR could bind different bacteria through five extracellular Ig domains and formed dimers. The activated CgIgR recruited CgSyk to promote CgERK phosphorylation. The CgIgR-mediated signaling promoted the production of immunoglobulin domain-containing proteins (CgICP-2 and CgLRRIG-1) through inducing CgH3K4me2. The produced CgICPs eventually facilitated hemocytes to phagocytize and eliminate V. splendidus. This study proposed that there was an ancient BCR-like molecule and BCR-like signaling in molluscs. : Biological Sciences; Immunology; Cell Biology Subject Areas: Biological Sciences, Immunology, Cell Biologyhttp://www.sciencedirect.com/science/article/pii/S2589004220300171
collection DOAJ
language English
format Article
sources DOAJ
author Jiejie Sun
Lingling Wang
Chuanyan Yang
Linsheng Song
spellingShingle Jiejie Sun
Lingling Wang
Chuanyan Yang
Linsheng Song
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
iScience
author_facet Jiejie Sun
Lingling Wang
Chuanyan Yang
Linsheng Song
author_sort Jiejie Sun
title An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
title_short An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
title_full An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
title_fullStr An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
title_full_unstemmed An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
title_sort ancient bcr-like signaling promotes icp production and hemocyte phagocytosis in oyster
publisher Elsevier
series iScience
issn 2589-0042
publishDate 2020-02-01
description Summary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the downstream response are still not clear in invertebrates. In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. CgIgR could bind different bacteria through five extracellular Ig domains and formed dimers. The activated CgIgR recruited CgSyk to promote CgERK phosphorylation. The CgIgR-mediated signaling promoted the production of immunoglobulin domain-containing proteins (CgICP-2 and CgLRRIG-1) through inducing CgH3K4me2. The produced CgICPs eventually facilitated hemocytes to phagocytize and eliminate V. splendidus. This study proposed that there was an ancient BCR-like molecule and BCR-like signaling in molluscs. : Biological Sciences; Immunology; Cell Biology Subject Areas: Biological Sciences, Immunology, Cell Biology
url http://www.sciencedirect.com/science/article/pii/S2589004220300171
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