Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology

Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology

Aberrant secretion and accumulation of α-synuclein (α-Syn) as well as the loss of parkin function are associated with the pathogenesis of Parkinson’s disease (PD). Our previous study suggested a functional interaction between those two proteins, showing that the extracellular α-Syn evoked post-trans...

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Bibliographic Details
Main Authors: Anna Wilkaniec, Anna M. Lenkiewicz, Lidia Babiec, Emilia Murawska, Henryk M. Jęśko, Magdalena Cieślik, Carsten Culmsee, Agata Adamczyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
α-synuclein (α-syn)
parkin
mitochondria dysfunction
mitophagy
PGC-1 alpha
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.591475/full

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