TAF1 plays a critical role in AML1-ETO driven leukemogenesis
AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leu...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12735-z |
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doaj-7c876bc2dac14cc194b471dadcb6299e2021-05-11T11:47:42ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12735-zTAF1 plays a critical role in AML1-ETO driven leukemogenesisYe Xu0Na Man1Daniel Karl2Concepcion Martinez3Fan Liu4Jun Sun5Camilo Jose Martinez6Gloria Mas Martin7Felipe Beckedorff8Fan Lai9Jingyin Yue10Alejandro Roisman11Sarah Greenblatt12Stephanie Duffort13Lan Wang14Xiaojian Sun15Maria Figueroa16Ramin Shiekhattar17Stephen Nimer18Sylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiDepartment of Medicine, Miller School of Medicine, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiSylvester Comprehensive Cancer Center, University of MiamiAML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.https://doi.org/10.1038/s41467-019-12735-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer |
| spellingShingle |
Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer TAF1 plays a critical role in AML1-ETO driven leukemogenesis Nature Communications |
| author_facet |
Ye Xu Na Man Daniel Karl Concepcion Martinez Fan Liu Jun Sun Camilo Jose Martinez Gloria Mas Martin Felipe Beckedorff Fan Lai Jingyin Yue Alejandro Roisman Sarah Greenblatt Stephanie Duffort Lan Wang Xiaojian Sun Maria Figueroa Ramin Shiekhattar Stephen Nimer |
| author_sort |
Ye Xu |
| title |
TAF1 plays a critical role in AML1-ETO driven leukemogenesis |
| title_short |
TAF1 plays a critical role in AML1-ETO driven leukemogenesis |
| title_full |
TAF1 plays a critical role in AML1-ETO driven leukemogenesis |
| title_fullStr |
TAF1 plays a critical role in AML1-ETO driven leukemogenesis |
| title_full_unstemmed |
TAF1 plays a critical role in AML1-ETO driven leukemogenesis |
| title_sort |
taf1 plays a critical role in aml1-eto driven leukemogenesis |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal. |
| url |
https://doi.org/10.1038/s41467-019-12735-z |
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