Identification of trans-eQTLs using mediation analysis with multiple mediators

Identification of trans-eQTLs using mediation analysis with multiple mediators

Abstract Background Mapping expression quantitative trait loci (eQTLs) has provided insight into gene regulation. Compared to cis-eQTLs, the regulatory mechanisms of trans-eQTLs are less known. Previous studies suggest that trans-eQTLs may regulate expression of remote genes by altering the expressi...

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Bibliographic Details
Main Authors: Nayang Shan, Zuoheng Wang, Lin Hou
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Bioinformatics
Subjects:
Trans-eQTL
Mediation analysis
Multiple mediators
Online Access:http://link.springer.com/article/10.1186/s12859-019-2651-6

Internet

http://link.springer.com/article/10.1186/s12859-019-2651-6

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