A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. The entry point for the virus is ACE2, which is a c...

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Bibliographic Details
Main Authors: Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
renin-angiotensin system
bradykinin
COVID-19
hyaluronic acid
pathogenesis
Online Access:https://elifesciences.org/articles/59177

Internet

https://elifesciences.org/articles/59177

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