Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study.
The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth.Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and sali...
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doaj-7cb1f8b44808437bb6e7ba168de68c392020-11-25T00:08:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017373210.1371/journal.pone.0173732Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study.Hui LimSioned PowellHelen C McnamaraA Forbes HowieAnn DoustMaria E BowmanRoger SmithJane E NormanSarah J StockThe objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth.Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries.No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated.Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.http://europepmc.org/articles/PMC5344513?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Lim Sioned Powell Helen C Mcnamara A Forbes Howie Ann Doust Maria E Bowman Roger Smith Jane E Norman Sarah J Stock |
spellingShingle |
Hui Lim Sioned Powell Helen C Mcnamara A Forbes Howie Ann Doust Maria E Bowman Roger Smith Jane E Norman Sarah J Stock Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. PLoS ONE |
author_facet |
Hui Lim Sioned Powell Helen C Mcnamara A Forbes Howie Ann Doust Maria E Bowman Roger Smith Jane E Norman Sarah J Stock |
author_sort |
Hui Lim |
title |
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. |
title_short |
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. |
title_full |
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. |
title_fullStr |
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. |
title_full_unstemmed |
Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study. |
title_sort |
placental hormone profiles as predictors of preterm birth in twin pregnancy: a prospective cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth.Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries.No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated.Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies. |
url |
http://europepmc.org/articles/PMC5344513?pdf=render |
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