Synthesis of Hafnium(IV) Polyaminoacetates

The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy N,N,N′,<i...

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Main Authors:	Alexandra T. Shulyak, Evgeniy O. Bortnikov, Alexey S. Kubasov, Nikita A. Selivanov, Alexey A. Lipengolts, Andrey P. Zhdanov, Alexander Yu. Bykov, Konstantin Yu. Zhizhin, Nikolai T. Kuznetsov
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Molecules
Subjects:	hafnium complexonates coordination chemistry DTPA contrast agent structure elucidation
Online Access:	https://www.mdpi.com/1420-3049/26/12/3725

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spelling	doaj-7cb4395e22bf43de8792102c23ee6b442021-07-01T00:33:03ZengMDPI AGMolecules1420-30492021-06-01263725372510.3390/molecules26123725Synthesis of Hafnium(IV) PolyaminoacetatesAlexandra T. Shulyak0Evgeniy O. Bortnikov1Alexey S. Kubasov2Nikita A. Selivanov3Alexey A. Lipengolts4Andrey P. Zhdanov5Alexander Yu. Bykov6Konstantin Yu. Zhizhin7Nikolai T. Kuznetsov8Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaOrganic Chemistry Department, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, IsraelKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaN.N. Blokhin National Medical Research Center of Oncology, Federal State Budgetary Institution, Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), Kashirskoye Shosse 24, 115478 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaKurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskiy pr. 31, 119991 Moscow, RussiaThe interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetraacetic acid (dpta), and <i>N</i>-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na<sub>2</sub>[Hf(NTA)<sub>2</sub>]·3H<sub>2</sub>O (<b>1</b>), Na[HfDTPA]·3H<sub>2</sub>O (<b>2</b>), [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] (<b>3</b>), and Na[Hf<sub>2</sub>(dpta)<sub>2</sub>]·7.5H<sub>2</sub>O·0.5C<sub>2</sub>H<sub>5</sub>OH (<b>4</b>) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.https://www.mdpi.com/1420-3049/26/12/3725hafniumcomplexonatescoordination chemistryDTPAcontrast agentstructure elucidation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov
spellingShingle	Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov Synthesis of Hafnium(IV) Polyaminoacetates Molecules hafnium complexonates coordination chemistry DTPA contrast agent structure elucidation
author_facet	Alexandra T. Shulyak Evgeniy O. Bortnikov Alexey S. Kubasov Nikita A. Selivanov Alexey A. Lipengolts Andrey P. Zhdanov Alexander Yu. Bykov Konstantin Yu. Zhizhin Nikolai T. Kuznetsov
author_sort	Alexandra T. Shulyak
title	Synthesis of Hafnium(IV) Polyaminoacetates
title_short	Synthesis of Hafnium(IV) Polyaminoacetates
title_full	Synthesis of Hafnium(IV) Polyaminoacetates
title_fullStr	Synthesis of Hafnium(IV) Polyaminoacetates
title_full_unstemmed	Synthesis of Hafnium(IV) Polyaminoacetates
title_sort	synthesis of hafnium(iv) polyaminoacetates
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-06-01
description	The interaction of hafnium(IV) salts (oxide-dichloride, chloride, and bromide) with nitrilotriacetic acid (NTA), diethylenetriamminepentaacetic acid (DTPA), 1,2-diaminocyclohexanetetraacetic acid (CDTA), 1,3-dipropylmino-2-hydroxy <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetraacetic acid (dpta), and <i>N</i>-(2-hydroxyethyl)ethylenediamine triacetic acid (HEDTA) has been studied. The corresponding complexes Na<sub>2</sub>[Hf(NTA)<sub>2</sub>]·3H<sub>2</sub>O (<b>1</b>), Na[HfDTPA]·3H<sub>2</sub>O (<b>2</b>), [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] (<b>3</b>), and Na[Hf<sub>2</sub>(dpta)<sub>2</sub>]·7.5H<sub>2</sub>O·0.5C<sub>2</sub>H<sub>5</sub>OH (<b>4</b>) have been isolated and characterized and their structures have been determined by single crystal X-ray diffraction. Biological studies of [HfCDTA(H<sub>2</sub>O)<sub>2</sub>] have shown that in 5% glucose solution this complex has low toxicity and good contrasting ability.
topic	hafnium complexonates coordination chemistry DTPA contrast agent structure elucidation
url	https://www.mdpi.com/1420-3049/26/12/3725
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Synthesis of Hafnium(IV) Polyaminoacetates

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