Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties

Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties

Abstract Background Although EGFR tyrosine kinase inhibitors (EGFR-TKIs) are beneficial to lung adenocarcinoma patients with sensitive EGFR mutations, resistance to these inhibitors induces a cancer stem cell (CSC) phenotype. Here, we clarify the function and molecular mechanism of shisa3 as a suppr...

Full description

Bibliographic Details
Main Authors: Jiahui Si, Yuanyuan Ma, Ji Wang Bi, Ying Xiong, Chao Lv, Shaolei Li, Nan Wu, Yue Yang
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Shisa3
Cancer stem cells
EGFR-TKI resistance
FGFR
mTOR
Online Access:https://doi.org/10.1186/s13046-019-1486-3

Similar Items

Similar Items