Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling in Continuous Flow

• Main Authors: Christophe Len, Sophie Bruniaux, Frederic Delbecq, Virinder S. Parmar
• Format: Article
• Language: English
• Published: MDPI AG 2017-05-01
• Series: Catalysts
• Subjects: palladium; continuous flow; Suzuki–Miyaura; cross-coupling
• Online Access: http://www.mdpi.com/2073-4344/7/5/146

Carbon–carbon cross-coupling reactions are among the most important processes in organic chemistry and Suzuki–Miyaura reactions are the most widely used protocols. For a decade, green chemistry and particularly catalysis and continuous flow, have shown immense potential in achieving the goals of “greener synthesis”. To date, it seems difficult to conceive the chemistry of the 21st century without the industrialization of continuous flow process in the area of pharmaceuticals, drugs, agrochemicals, polymers, etc. A large variety of palladium Suzuki–Miyaura cross-coupling reactions have been developed using a continuous flow sequence for preparing the desired biaryl derivatives. Our objective is to focus this review on the continuous flow Suzuki–Miyaura cross-coupling using homogeneous and heterogeneous catalysts.