Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review
Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain injury, causes severe neurological symptoms such as sensory and motor deficits. Currently, there is no effective therapeutic method to restore neurological function because the adult CNS has limited capaci...
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doaj-7cc96506682f4b13bbe7b546e421a1ed2020-11-25T04:06:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-01218116811610.3390/ijms21218116Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A ReviewAkiko Uyeda0Rieko Muramatsu1Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, JapanDepartment of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, JapanCentral nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain injury, causes severe neurological symptoms such as sensory and motor deficits. Currently, there is no effective therapeutic method to restore neurological function because the adult CNS has limited capacity to regenerate after injury. Many efforts have been made to understand the molecular and cellular mechanisms underlying CNS regeneration and to establish novel therapeutic methods based on these mechanisms, with a variety of strategies including cell transplantation, modulation of cell intrinsic molecular mechanisms, and therapeutic targeting of the pathological nature of the extracellular environment in CNS injury. In this review, we will focus on the mechanisms that regulate CNS regeneration, highlighting the history, recent efforts, and questions left unanswered in this field.https://www.mdpi.com/1422-0067/21/21/8116axon regenerationsproutingspinal cord injuryremyelinationBBBsystemic factor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akiko Uyeda Rieko Muramatsu |
spellingShingle |
Akiko Uyeda Rieko Muramatsu Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review International Journal of Molecular Sciences axon regeneration sprouting spinal cord injury remyelination BBB systemic factor |
author_facet |
Akiko Uyeda Rieko Muramatsu |
author_sort |
Akiko Uyeda |
title |
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review |
title_short |
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review |
title_full |
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review |
title_fullStr |
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review |
title_full_unstemmed |
Molecular Mechanisms of Central Nervous System Axonal Regeneration and Remyelination: A Review |
title_sort |
molecular mechanisms of central nervous system axonal regeneration and remyelination: a review |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-10-01 |
description |
Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain injury, causes severe neurological symptoms such as sensory and motor deficits. Currently, there is no effective therapeutic method to restore neurological function because the adult CNS has limited capacity to regenerate after injury. Many efforts have been made to understand the molecular and cellular mechanisms underlying CNS regeneration and to establish novel therapeutic methods based on these mechanisms, with a variety of strategies including cell transplantation, modulation of cell intrinsic molecular mechanisms, and therapeutic targeting of the pathological nature of the extracellular environment in CNS injury. In this review, we will focus on the mechanisms that regulate CNS regeneration, highlighting the history, recent efforts, and questions left unanswered in this field. |
topic |
axon regeneration sprouting spinal cord injury remyelination BBB systemic factor |
url |
https://www.mdpi.com/1422-0067/21/21/8116 |
work_keys_str_mv |
AT akikouyeda molecularmechanismsofcentralnervoussystemaxonalregenerationandremyelinationareview AT riekomuramatsu molecularmechanismsofcentralnervoussystemaxonalregenerationandremyelinationareview |
_version_ |
1724431345330946048 |