Synthesis and Evaluation of a Chitosan Oligosaccharide-Streptomycin Conjugate against Pseudomonas aeruginosa Biofilms

Synthesis and Evaluation of a Chitosan Oligosaccharide-Streptomycin Conjugate against Pseudomonas aeruginosa Biofilms

Microbial biofilms are considerably more resistant to antibiotics than planktonic cells. It has been reported that chitosan coupling with the aminoglycoside antibiotic streptomycin dramatically disrupted biofilms of several Gram-positive bacteria. This finding suggested the application of the covale...

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Bibliographic Details
Main Authors: Ruilian Li, Xianghua Yuan, Jinhua Wei, Xiafei Zhang, Gong Cheng, Zhuo A. Wang, Yuguang Du
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Marine Drugs
Subjects:
chitosan oligosaccharides
streptomycin
Pseudomonas aeruginosa
biofilms
conjugation
Online Access:http://www.mdpi.com/1660-3397/17/1/43

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