DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system with presumed autoimmune origin. It is largely accepted that the inflammatory induced loss of axons and neurons is the underlying cause of disability in multiple sclerosis patients. Diffusion tensor im...
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doaj-7cd2d209539a49f89ebade721b75c7fd2020-11-25T02:09:54ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942011-06-01102737610.37897/RJN.2011.2.2DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSISA. Roceanu0M. Onu1V. Ferastraoaru2E. Tarta3F. Preoteasa4F. Antochi5O. Bajenaru6Department of Neurology, Emergency University Hospital, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaJacobi Medical Center, Bronx NY, USAUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaUniversity of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaDepartment of Neurology, Emergency University Hospital, Bucharest, RomaniaDepartment of Neurology, Emergency University Hospital, Bucharest, Romania; University of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system with presumed autoimmune origin. It is largely accepted that the inflammatory induced loss of axons and neurons is the underlying cause of disability in multiple sclerosis patients. Diffusion tensor imaging (DTI) is a new neuroimaging technique based on MRI, used for quantification of water diffusion in tissues. We performed DTI to 12 MS patients in order to assess idiffusion parameters (fractional anisotropy, mean diffusivity, longitudinal diffusivity (F1) and transversal diffusivities (F2, F3). We foud that F1 may be used as an indicator of axonal loss in human as well, proving a good correlation with degree of disability.https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2011-Nr.2/RJN_2011_2_Art-02.pdfmultiple scleorsis (ms)diffusion tensor imaging (dti)axonal lossdisability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Roceanu M. Onu V. Ferastraoaru E. Tarta F. Preoteasa F. Antochi O. Bajenaru |
spellingShingle |
A. Roceanu M. Onu V. Ferastraoaru E. Tarta F. Preoteasa F. Antochi O. Bajenaru DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS Romanian Journal of Neurology multiple scleorsis (ms) diffusion tensor imaging (dti) axonal loss disability |
author_facet |
A. Roceanu M. Onu V. Ferastraoaru E. Tarta F. Preoteasa F. Antochi O. Bajenaru |
author_sort |
A. Roceanu |
title |
DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS |
title_short |
DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS |
title_full |
DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS |
title_fullStr |
DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS |
title_full_unstemmed |
DTI PARAMETER CHANGES IN AXONAL LOSS DUE TO MULTIPLE SCLEROSIS |
title_sort |
dti parameter changes in axonal loss due to multiple sclerosis |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Neurology |
issn |
1843-8148 2069-6094 |
publishDate |
2011-06-01 |
description |
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system with presumed autoimmune origin. It is largely accepted that the inflammatory induced loss of axons and neurons is the underlying cause of disability in multiple sclerosis patients.
Diffusion tensor imaging (DTI) is a new neuroimaging technique based on MRI, used for quantification of water diffusion in tissues.
We performed DTI to 12 MS patients in order to assess idiffusion parameters (fractional anisotropy, mean diffusivity, longitudinal diffusivity (F1) and transversal diffusivities (F2, F3). We foud that F1 may be used as an indicator of axonal loss in human as well, proving a good correlation with degree of disability. |
topic |
multiple scleorsis (ms) diffusion tensor imaging (dti) axonal loss disability |
url |
https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2011-Nr.2/RJN_2011_2_Art-02.pdf |
work_keys_str_mv |
AT aroceanu dtiparameterchangesinaxonallossduetomultiplesclerosis AT monu dtiparameterchangesinaxonallossduetomultiplesclerosis AT vferastraoaru dtiparameterchangesinaxonallossduetomultiplesclerosis AT etarta dtiparameterchangesinaxonallossduetomultiplesclerosis AT fpreoteasa dtiparameterchangesinaxonallossduetomultiplesclerosis AT fantochi dtiparameterchangesinaxonallossduetomultiplesclerosis AT obajenaru dtiparameterchangesinaxonallossduetomultiplesclerosis |
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1724921801132212224 |