Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal
<p><strong>Background & Objectives: </strong>Acute Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. The study was conducted with the objectiv...
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doaj-7cdf4f39c20745858781db3925bcf2fe2020-11-24T23:53:49ZengCollege of Medical SciencesJournal of College of Medical Sciences-Nepal2091-06572091-06732017-07-0113228428910.3126/jcmsn.v13i2.1646313754Adverse drug reactions of antihypertensive agents at tertiary care hospital in central NepalSabita Paudel0M Sudarsana Chetty1Shankar Laudari2Nuwadatta Subedi3Dept of Pharmacology, Gandaki Medical College, KaskiCollege of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan, NepalCollege of Medical Sciences-Teaching Hospital, Bharatpur, Chitwan, NepalGandaki Medical College, Pokhara<p><strong>Background & Objectives: </strong>Acute Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. The study was conducted with the objective to examine the incidence of different types of adverse drug reactions in drug treated hypertensive patients.</p><p><strong>Materials & Methods:</strong> Patients (n=382) who received antihypertensive agents were selected and interviewed using a standardized questionnaire. The Naranjo Algorithm, which categorizes the causality relationship into definite, probable, possible and doubtful, was used for the assessment of the exact nature of Adverse drug reaction (ADR).</p><p><strong>Results: </strong>Calcium channel blockers (CCBs) were the drug class with highest number (22 or 32.84%) of ADRs followed by Angiotensin-converting enzyme Inhibitors (ACEI) in 17 (25.38%), Angiotensin Receptor Blockers (ARB) in 12 (17.91%), diuretics in 10 (14.92%) and beta adrenergic antagonist in six (8.95%). Cardiovascular system (40 or 59.70%) was the most affected followed by central nervous system (16 or 23.88%) and respiratory and dermatological system each in 11 (16.42%) cases. On Naranjo’s probability scale, nine (13.4%) of the ADRs were definite, 39 (58.2%) possible, 16 (23.9%) probable and three (4.5%) doubtful. </p><p><strong>Conclusion: </strong>Calcium channel blockers were mostly associated with ADRs while Cardiovascular system was the most frequently affected.</p><p> </p>http://www.nepjol.info/index.php/JCMSN/article/view/16463Adverse drug reactionsAntihypertensive agentsNaranjo Algorithm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sabita Paudel M Sudarsana Chetty Shankar Laudari Nuwadatta Subedi |
spellingShingle |
Sabita Paudel M Sudarsana Chetty Shankar Laudari Nuwadatta Subedi Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal Journal of College of Medical Sciences-Nepal Adverse drug reactions Antihypertensive agents Naranjo Algorithm |
author_facet |
Sabita Paudel M Sudarsana Chetty Shankar Laudari Nuwadatta Subedi |
author_sort |
Sabita Paudel |
title |
Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal |
title_short |
Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal |
title_full |
Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal |
title_fullStr |
Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal |
title_full_unstemmed |
Adverse drug reactions of antihypertensive agents at tertiary care hospital in central Nepal |
title_sort |
adverse drug reactions of antihypertensive agents at tertiary care hospital in central nepal |
publisher |
College of Medical Sciences |
series |
Journal of College of Medical Sciences-Nepal |
issn |
2091-0657 2091-0673 |
publishDate |
2017-07-01 |
description |
<p><strong>Background & Objectives: </strong>Acute Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. The study was conducted with the objective to examine the incidence of different types of adverse drug reactions in drug treated hypertensive patients.</p><p><strong>Materials & Methods:</strong> Patients (n=382) who received antihypertensive agents were selected and interviewed using a standardized questionnaire. The Naranjo Algorithm, which categorizes the causality relationship into definite, probable, possible and doubtful, was used for the assessment of the exact nature of Adverse drug reaction (ADR).</p><p><strong>Results: </strong>Calcium channel blockers (CCBs) were the drug class with highest number (22 or 32.84%) of ADRs followed by Angiotensin-converting enzyme Inhibitors (ACEI) in 17 (25.38%), Angiotensin Receptor Blockers (ARB) in 12 (17.91%), diuretics in 10 (14.92%) and beta adrenergic antagonist in six (8.95%). Cardiovascular system (40 or 59.70%) was the most affected followed by central nervous system (16 or 23.88%) and respiratory and dermatological system each in 11 (16.42%) cases. On Naranjo’s probability scale, nine (13.4%) of the ADRs were definite, 39 (58.2%) possible, 16 (23.9%) probable and three (4.5%) doubtful. </p><p><strong>Conclusion: </strong>Calcium channel blockers were mostly associated with ADRs while Cardiovascular system was the most frequently affected.</p><p> </p> |
topic |
Adverse drug reactions Antihypertensive agents Naranjo Algorithm |
url |
http://www.nepjol.info/index.php/JCMSN/article/view/16463 |
work_keys_str_mv |
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