Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis
Background: Increased aortic stiffness has been found to be associated with cognitive function decline, but the evidence is still under debate. It is of great significance to elucidate the evidence in this debate to help make primary prevention decisions to slow cognitive decline in our routine clin...
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2021-06-01
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doaj-7ce1811bb92642b6ab564888bf99e66b2021-06-23T07:11:27ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-06-011310.3389/fnagi.2021.680205680205Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-AnalysisQian LiuJinghuan FangChaohua CuiShuju DongLijie GaoJiajia BaoYanbo LiMengmeng MaNing ChenLi HeBackground: Increased aortic stiffness has been found to be associated with cognitive function decline, but the evidence is still under debate. It is of great significance to elucidate the evidence in this debate to help make primary prevention decisions to slow cognitive decline in our routine clinical practice.Methods: Electronic databases of PubMed, EMBASE, and Cochrane Library were systematically searched to identify peer-reviewed articles published in English from January 1, 1986, to March 16, 2020, that reported the association between aortic stiffness and cognitive function. Studies that reported the association between aortic pulse wave velocity (PWV) and cognitive function, cognitive impairment, and dementia were included in the analysis.Results: Thirty-nine studies were included in the qualitative analysis, and 29 studies were included in the quantitative analysis. The aortic PWV was inversely associated with memory and processing speed in the cross-sectional analysis. In the longitudinal analysis, the high category of aortic PWV was 44% increased risk of cognitive impairment (OR 1.44; 95% CI 1.24–1.85) compared with low PWV, and the risk of cognitive impairment increased 3.9% (OR 1.039; 95% CI 1.005–1.073) per 1 m/s increase in aortic PWV. Besides, meta-regression analysis showed that age significantly increased the association between high aortic PWV and cognitive impairment risk.Conclusion: Aortic stiffness measured by aortic PWV was inversely associated with memory and processing speed and could be an independent predictor for cognitive impairment, especially for older individuals.https://www.frontiersin.org/articles/10.3389/fnagi.2021.680205/fullaortic stiffnesspulse wave velocitycognitive impairmentvascular dementiaaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qian Liu Jinghuan Fang Chaohua Cui Shuju Dong Lijie Gao Jiajia Bao Yanbo Li Mengmeng Ma Ning Chen Li He |
spellingShingle |
Qian Liu Jinghuan Fang Chaohua Cui Shuju Dong Lijie Gao Jiajia Bao Yanbo Li Mengmeng Ma Ning Chen Li He Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis Frontiers in Aging Neuroscience aortic stiffness pulse wave velocity cognitive impairment vascular dementia aging |
author_facet |
Qian Liu Jinghuan Fang Chaohua Cui Shuju Dong Lijie Gao Jiajia Bao Yanbo Li Mengmeng Ma Ning Chen Li He |
author_sort |
Qian Liu |
title |
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis |
title_short |
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis |
title_full |
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis |
title_fullStr |
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis |
title_sort |
association of aortic stiffness and cognitive decline: a systematic review and meta-analysis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-06-01 |
description |
Background: Increased aortic stiffness has been found to be associated with cognitive function decline, but the evidence is still under debate. It is of great significance to elucidate the evidence in this debate to help make primary prevention decisions to slow cognitive decline in our routine clinical practice.Methods: Electronic databases of PubMed, EMBASE, and Cochrane Library were systematically searched to identify peer-reviewed articles published in English from January 1, 1986, to March 16, 2020, that reported the association between aortic stiffness and cognitive function. Studies that reported the association between aortic pulse wave velocity (PWV) and cognitive function, cognitive impairment, and dementia were included in the analysis.Results: Thirty-nine studies were included in the qualitative analysis, and 29 studies were included in the quantitative analysis. The aortic PWV was inversely associated with memory and processing speed in the cross-sectional analysis. In the longitudinal analysis, the high category of aortic PWV was 44% increased risk of cognitive impairment (OR 1.44; 95% CI 1.24–1.85) compared with low PWV, and the risk of cognitive impairment increased 3.9% (OR 1.039; 95% CI 1.005–1.073) per 1 m/s increase in aortic PWV. Besides, meta-regression analysis showed that age significantly increased the association between high aortic PWV and cognitive impairment risk.Conclusion: Aortic stiffness measured by aortic PWV was inversely associated with memory and processing speed and could be an independent predictor for cognitive impairment, especially for older individuals. |
topic |
aortic stiffness pulse wave velocity cognitive impairment vascular dementia aging |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.680205/full |
work_keys_str_mv |
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