Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso.
Serogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina...
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doaj-7ce2e92b38864f16bcd0cc3ceac00cad2020-11-24T21:41:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0165e1951310.1371/journal.pone.0019513Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso.Isabelle DelrieuSeydou YaroTsidi A S TamekloéBerthe-Marie Njanpop-LafourcadeHaoua TallPhilippe JaillardMacaire S OuedraogoKossi BadziklouOumarou SanouAly DraboBradford D GessnerJean L KambouJudith E MuellerSerogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina Faso during 2006-2010. Cerebrospinal fluid specimens were analyzed by PCR. In Togo during 2006-2009, NmX accounted for 16% of the 702 confirmed bacterial meningitis cases. Kozah district experienced an NmX outbreak in March 2007 with an NmX seasonal cumulative incidence of 33/100,000. In Burkina Faso during 2007-2010, NmX accounted for 7% of the 778 confirmed bacterial meningitis cases, with an increase from 2009 to 2010 (4% to 35% of all confirmed cases, respectively). In 2010, NmX epidemics occurred in northern and central regions of Burkina Faso; the highest district cumulative incidence of NmX was estimated as 130/100,000 during March-April. Although limited to a few districts, we have documented NmX meningitis epidemics occurring with a seasonal incidence previously only reported in the meningitis belt for NmW135 and NmA, which argues for development of an NmX vaccine.http://europepmc.org/articles/PMC3098835?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isabelle Delrieu Seydou Yaro Tsidi A S Tamekloé Berthe-Marie Njanpop-Lafourcade Haoua Tall Philippe Jaillard Macaire S Ouedraogo Kossi Badziklou Oumarou Sanou Aly Drabo Bradford D Gessner Jean L Kambou Judith E Mueller |
spellingShingle |
Isabelle Delrieu Seydou Yaro Tsidi A S Tamekloé Berthe-Marie Njanpop-Lafourcade Haoua Tall Philippe Jaillard Macaire S Ouedraogo Kossi Badziklou Oumarou Sanou Aly Drabo Bradford D Gessner Jean L Kambou Judith E Mueller Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. PLoS ONE |
author_facet |
Isabelle Delrieu Seydou Yaro Tsidi A S Tamekloé Berthe-Marie Njanpop-Lafourcade Haoua Tall Philippe Jaillard Macaire S Ouedraogo Kossi Badziklou Oumarou Sanou Aly Drabo Bradford D Gessner Jean L Kambou Judith E Mueller |
author_sort |
Isabelle Delrieu |
title |
Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. |
title_short |
Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. |
title_full |
Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. |
title_fullStr |
Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. |
title_full_unstemmed |
Emergence of epidemic Neisseria meningitidis serogroup X meningitis in Togo and Burkina Faso. |
title_sort |
emergence of epidemic neisseria meningitidis serogroup x meningitis in togo and burkina faso. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Serogroup X meningococci (NmX) historically have caused sporadic and clustered meningitis cases in sub-Saharan Africa. To study recent NmX epidemiology, we analyzed data from population-based, sentinel and passive surveillance, and outbreak investigations of bacterial meningitis in Togo and Burkina Faso during 2006-2010. Cerebrospinal fluid specimens were analyzed by PCR. In Togo during 2006-2009, NmX accounted for 16% of the 702 confirmed bacterial meningitis cases. Kozah district experienced an NmX outbreak in March 2007 with an NmX seasonal cumulative incidence of 33/100,000. In Burkina Faso during 2007-2010, NmX accounted for 7% of the 778 confirmed bacterial meningitis cases, with an increase from 2009 to 2010 (4% to 35% of all confirmed cases, respectively). In 2010, NmX epidemics occurred in northern and central regions of Burkina Faso; the highest district cumulative incidence of NmX was estimated as 130/100,000 during March-April. Although limited to a few districts, we have documented NmX meningitis epidemics occurring with a seasonal incidence previously only reported in the meningitis belt for NmW135 and NmA, which argues for development of an NmX vaccine. |
url |
http://europepmc.org/articles/PMC3098835?pdf=render |
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