Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers
**Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and a...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Columbia Data Analytics, LLC
|
Series: | Journal of Health Economics and Outcomes Research |
Online Access: | http://jheor.scholasticahq.com/article/9842-preferences-for-attention-deficit-hyperactivity-disorder-adhd-non-stimulant-treatment-characteristics-among-children-and-adolescents-with-adhd-and-their-caregivers.pdf |
id |
doaj-7cf2505f2eab4ecdb556b525af8ad5eb |
---|---|
record_format |
Article |
spelling |
doaj-7cf2505f2eab4ecdb556b525af8ad5eb2020-11-25T01:34:18ZengColumbia Data Analytics, LLCJournal of Health Economics and Outcomes Research2327-2236Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their CaregiversEmuella FloodKavita GajriaVanja SikiricaPaul HodgkinsM. Haim ErderFrank LopezDaniel Connor**Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and atomoxetine (ATX) are two non-stimulant medications approved in the United States for the treatment of ADHD. **Objective:** To identify non-stimulant ADHD medication attributes important to caregivers/patients. **Methods:** US caregivers of ADHD patients (6–17 years) and child/adolescent patients (10–17 years) completed an adaptive conjoint analysis survey. Respondents selected between hypothetical treatments with different attributes. Ordinary least-squares and hierarchical Bayes regression using Sawtooth Software were used to calculate utilities, importance ratings, and preferences. **Results:** 483 caregivers (mean age: 41.9 years, standard deviation [SD]: 8.7; 75% female) and 211 children/adolescents (mean age: 14.5 years, SD: 2.2; 70% male) completed the survey. Based on importance ratings, the most influential attributes for both caregivers and children/adolescents were chance of somnolence, efficacy, and for caregivers, effect on oppositionality and black box warning. Most caregivers (95.3%) and children/adolescents (93.8%) preferred GXR over ATX. In several sensitivity analyses in which attribute levels varied, GXR remained the preferred medication with the exception of one scenario. **Conclusions:** Children/adolescents and caregivers demonstrated in this study that they can clearly express their preferences for treatment attributes and treatment choices; in this case they preferred GXR to ATX. Patients and caregiver preferences could be useful inputs to the treatment selection decision-making process.http://jheor.scholasticahq.com/article/9842-preferences-for-attention-deficit-hyperactivity-disorder-adhd-non-stimulant-treatment-characteristics-among-children-and-adolescents-with-adhd-and-their-caregivers.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor |
spellingShingle |
Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers Journal of Health Economics and Outcomes Research |
author_facet |
Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor |
author_sort |
Emuella Flood |
title |
Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
title_short |
Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
title_full |
Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
title_fullStr |
Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
title_full_unstemmed |
Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
title_sort |
preferences for attention-deficit/hyperactivity disorder (adhd) non-stimulant treatment characteristics among children and adolescents with adhd and their caregivers |
publisher |
Columbia Data Analytics, LLC |
series |
Journal of Health Economics and Outcomes Research |
issn |
2327-2236 |
description |
**Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and atomoxetine (ATX) are two non-stimulant medications approved in the United States for the treatment of ADHD.
**Objective:** To identify non-stimulant ADHD medication attributes important to caregivers/patients.
**Methods:** US caregivers of ADHD patients (6–17 years) and child/adolescent patients (10–17 years) completed an adaptive conjoint analysis survey. Respondents selected between hypothetical treatments with different attributes. Ordinary least-squares and hierarchical Bayes regression using Sawtooth Software were used to calculate utilities, importance ratings, and preferences.
**Results:** 483 caregivers (mean age: 41.9 years, standard deviation [SD]: 8.7; 75% female) and 211 children/adolescents (mean age: 14.5 years, SD: 2.2; 70% male) completed the survey. Based on importance ratings, the most influential attributes for both caregivers and children/adolescents were chance of somnolence, efficacy, and for caregivers, effect on oppositionality and black box warning. Most caregivers (95.3%) and children/adolescents (93.8%) preferred GXR over ATX. In several sensitivity analyses in which attribute levels varied, GXR remained the preferred medication with the exception of one scenario.
**Conclusions:** Children/adolescents and caregivers demonstrated in this study that they can clearly express their preferences for treatment attributes and treatment choices; in this case they preferred GXR to ATX. Patients and caregiver preferences could be useful inputs to the treatment selection decision-making process. |
url |
http://jheor.scholasticahq.com/article/9842-preferences-for-attention-deficit-hyperactivity-disorder-adhd-non-stimulant-treatment-characteristics-among-children-and-adolescents-with-adhd-and-their-caregivers.pdf |
work_keys_str_mv |
AT emuellaflood preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT kavitagajria preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT vanjasikirica preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT paulhodgkins preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT mhaimerder preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT franklopez preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers AT danielconnor preferencesforattentiondeficithyperactivitydisorderadhdnonstimulanttreatmentcharacteristicsamongchildrenandadolescentswithadhdandtheircaregivers |
_version_ |
1725073226818650112 |