Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance

Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance

Inhibition of the megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2, also named PTPN9) activity has been shown to be a potential therapeutic strategy for the treatment of type 2 diabetes. Previously, we reported that PTP-MEG2 knockdown enhances adenosine monophosphate activated protein kinase (...

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Bibliographic Details
Main Authors: Sun-Young Yoon, Jae Sik Yu, Ji Young Hwang, Hae Min So, Seung Oh Seo, Jung Kyu Kim, Tae Su Jang, Sang J. Chung, Ki Hyun Kim
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
protein tyrosine phosphatases (PTPs)
PTP-MEG2
phloridzin
type 2 diabetes
glucose-uptake
Online Access:https://www.mdpi.com/1420-3049/26/6/1612

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