The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial–mesenchymal transition, and immune response

The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial–mesenchymal transition, and immune response

Abstract Background Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1 (EWSR1)-Wilm’s tumor suppressor (WT1) translocation. We used whole-exome sequen...

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Bibliographic Details
Main Authors: Andrea Devecchi, Loris De Cecco, Matteo Dugo, Donata Penso, Gianpaolo Dagrada, Silvia Brich, Silvia Stacchiotti, Marialuisa Sensi, Silvana Canevari, Silvana Pilotti
Format: Article
Language:English
Published: Wiley 2018-11-01
Series:Cancer Communications
Subjects:
Desmoplastic small round cell tumor
Whole-exome sequencing
Somatic mutations
Copy number alterations
Chromosome imbalance
DNA damage response
Online Access:http://link.springer.com/article/10.1186/s40880-018-0339-3

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