| Summary: | Cytokine levels in nasal discharge reflect the inflammatory status of the nasal mucosa. The aim of the paper was to compare the concentrations of cytokines in nasal discharge in allergic and non-allergic patients with nasal polyps (NP). Thirty patients with NP (13 atopic and 17 non-atopic) were included in this study. Samples of nasal discharge were collected from nasal cavities of all 30 subjects. The levels of TNF-α, TNF- β, IL-1β, IL-2, IL-12, IFN-γ, IL-4, IL-5, IL-6, IL-10, and IL-8 in nasal discharge were measured using commercial flow cytometric kit. We found significantly higher concentrations of IL-4 (p<0.01), IL-5 (p<0.05), IL-6 (p<0.05) and TNF-β (p<0.05) in allergic patients with NP than in non-allergic. Polyps in non-atopic and atopic patients have different immunological patterns.
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