Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature

• Main Authors: Massimo Luca Castellazzi, Samantha Bosis, Irene Borzani, Claudia Tagliabue, Raffaella Pinzani, Paola Marchisio, Giada Maria di Pietro
• Format: Article
• Language: English
• Published: BMC 2021-07-01
• Series: Italian Journal of Pediatrics
• Subjects: Panton-valentine leukocidin; Staphylococcus aureus; Children; Infection
• Online Access: https://doi.org/10.1186/s13052-021-01105-5

Abstract Background Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome. Case presentation This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery. Conclusion Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.