The application of histone deacetylases inhibitors in glioblastoma

The application of histone deacetylases inhibitors in glioblastoma

Abstract The epigenetic abnormality is generally accepted as the key to cancer initiation. Epigenetics that ensure the somatic inheritance of differentiated state is defined as a crucial factor influencing malignant phenotype without altering genotype. Histone modification is one such alteration pla...

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Bibliographic Details
Main Authors: Rui Chen, Mengxian Zhang, Yangmei Zhou, Wenjing Guo, Ming Yi, Ziyan Zhang, Yanpeng Ding, Yali Wang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
glioblastoma
epigenetic
histone acetylation, histone deacetylation
histone deacetylases inhibitors
gene expression
Online Access:http://link.springer.com/article/10.1186/s13046-020-01643-6

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