Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty
Objectives:To investigate the corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty (PKP).Materials and Methods:Thirty-five patients (70 eyes) were enrolled to this prospective study. Operated and contralateral keratoconic eyes were defined as Group 1 and 2, respect...
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Galenos Yayinevi
2018-08-01
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doaj-7d1627d6281648fcb59f0e40f5cdea982020-11-25T00:29:12ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612018-08-0148417117710.4274/tjo.7966413049054Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating KeratoplastyHamidu Gobeka0Özlem Barut Selver1Melis Palamar Onay2Sait Eğrilmez3Ayşe Yağcı4 Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey Ege University Faculty of Medicine, Department of Ophthalmology, İzmir, Turkey Objectives:To investigate the corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty (PKP).Materials and Methods:Thirty-five patients (70 eyes) were enrolled to this prospective study. Operated and contralateral keratoconic eyes were defined as Group 1 and 2, respectively. All patients underwent ophthalmological examination and measurements of corneal biomechanical properties by Ocular Response Analyzer (ORA), intraocular pressure (IOP) by Goldmann applanation tonometry, and central corneal thickness (CCT) by Pentacam. Shapiro-Wilk W test was performed to test normality of the data. The statistical significance was evaluated with the paired t-test and Wilcoxon signed ranks test. Pearson correlation and Spearman rho tests were used for correlation analysis.Results:The average age and male/female ratio were 31.34±11.65 (15-60) years and 21/14, respectively. The mean values of the data obtained from Group 1 and 2 respectively were: corneal hysteresis (CH): 9.35±1.66, 8.18±1.84 mmHg (p=0.013), corneal resistance factor (CRF): 9.48±1.96, 7.14±2.05 mmHg (p<0.001), IOPcc: 16.90±4.32, 14.26±3.69 mmHg (p=0.004), IOPg: 15.45±4.61, 10.91±3.97 mmHg (p<0.001), IOPapl: 14.26±3.11, 13.09±2.54 mmHg (p=0.046), and central corneal thickness (CCT): 545.64±60.82, 442.60±68.14 μM (p<0.001). The positive correlation between CH and CRF was moderate (r=0.444) in Group 1 and strong (r=0.770) in Group 2. There was a moderate negative correlation between CH and IOPcc in both groups (r=-0.426, r=-0.423), but CH was not correlated with IOPg or IOPapl in either group. There were weak to strong positive correlations between CRF and all IOP values in both groups. There was no correlation between CRF and CCT in Group 1 (r=0.075) and a very weak correlation in Group 2 (r=0.237). Only IOPcc and IOPg were strongly correlated in both groups.Conclusion:Better understanding of corneal biomechanical properties is essential for elucidating the pathophysiology and diagnosis of several corneal pathologies such as keratoconus. The biomechanical properties of keratoconic eyes seem to be closer to normal values after PKP. http://www.oftalmoloji.org/archives/archive-detail/article-preview/corneal-biomechanical-properties-of-keratoconic-ey/19559 Corneal biomechanical propertiesOcular Response Analyzerkeratoconuspenetrating keratoplasty |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hamidu Gobeka Özlem Barut Selver Melis Palamar Onay Sait Eğrilmez Ayşe Yağcı |
spellingShingle |
Hamidu Gobeka Özlem Barut Selver Melis Palamar Onay Sait Eğrilmez Ayşe Yağcı Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty Türk Oftalmoloji Dergisi Corneal biomechanical properties Ocular Response Analyzer keratoconus penetrating keratoplasty |
author_facet |
Hamidu Gobeka Özlem Barut Selver Melis Palamar Onay Sait Eğrilmez Ayşe Yağcı |
author_sort |
Hamidu Gobeka |
title |
Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty |
title_short |
Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty |
title_full |
Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty |
title_fullStr |
Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty |
title_full_unstemmed |
Corneal Biomechanical Properties of Keratoconic Eyes Following Penetrating Keratoplasty |
title_sort |
corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty |
publisher |
Galenos Yayinevi |
series |
Türk Oftalmoloji Dergisi |
issn |
1300-0659 2147-2661 |
publishDate |
2018-08-01 |
description |
Objectives:To investigate the corneal biomechanical properties of keratoconic eyes following penetrating keratoplasty (PKP).Materials and Methods:Thirty-five patients (70 eyes) were enrolled to this prospective study. Operated and contralateral keratoconic eyes were defined as Group 1 and 2, respectively. All patients underwent ophthalmological examination and measurements of corneal biomechanical properties by Ocular Response Analyzer (ORA), intraocular pressure (IOP) by Goldmann applanation tonometry, and central corneal thickness (CCT) by Pentacam. Shapiro-Wilk W test was performed to test normality of the data. The statistical significance was evaluated with the paired t-test and Wilcoxon signed ranks test. Pearson correlation and Spearman rho tests were used for correlation analysis.Results:The average age and male/female ratio were 31.34±11.65 (15-60) years and 21/14, respectively. The mean values of the data obtained from Group 1 and 2 respectively were: corneal hysteresis (CH): 9.35±1.66, 8.18±1.84 mmHg (p=0.013), corneal resistance factor (CRF): 9.48±1.96, 7.14±2.05 mmHg (p<0.001), IOPcc: 16.90±4.32, 14.26±3.69 mmHg (p=0.004), IOPg: 15.45±4.61, 10.91±3.97 mmHg (p<0.001), IOPapl: 14.26±3.11, 13.09±2.54 mmHg (p=0.046), and central corneal thickness (CCT): 545.64±60.82, 442.60±68.14 μM (p<0.001). The positive correlation between CH and CRF was moderate (r=0.444) in Group 1 and strong (r=0.770) in Group 2. There was a moderate negative correlation between CH and IOPcc in both groups (r=-0.426, r=-0.423), but CH was not correlated with IOPg or IOPapl in either group. There were weak to strong positive correlations between CRF and all IOP values in both groups. There was no correlation between CRF and CCT in Group 1 (r=0.075) and a very weak correlation in Group 2 (r=0.237). Only IOPcc and IOPg were strongly correlated in both groups.Conclusion:Better understanding of corneal biomechanical properties is essential for elucidating the pathophysiology and diagnosis of several corneal pathologies such as keratoconus. The biomechanical properties of keratoconic eyes seem to be closer to normal values after PKP. |
topic |
Corneal biomechanical properties Ocular Response Analyzer keratoconus penetrating keratoplasty |
url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/corneal-biomechanical-properties-of-keratoconic-ey/19559
|
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