The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease
Abstract Structural covariance assesses similarities in gray matter between brain regions and can be applied to study networks of the brain. In this study, we explored correlations between structural covariance networks (SCNs) and cognitive impairment in Parkinson’s disease patients. 101 PD patients...
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doaj-7d17494e599f42f5998bafd8b4d87ca92021-01-17T12:42:16ZengNature Publishing GroupScientific Reports2045-23222021-01-011111910.1038/s41598-020-79403-xThe corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's diseaseYueh-Sheng Chen0Hsiu-Ling Chen1Cheng-Hsien Lu2Chih-Ying Lee3Kun-Hsien Chou4Meng-Hsiang Chen5Chiun-Chieh Yu6Yun-Ru Lai7Pi-Ling Chiang8Wei-Che Lin9Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineBrain Research Center, National Yang-Ming UniversityDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of MedicineAbstract Structural covariance assesses similarities in gray matter between brain regions and can be applied to study networks of the brain. In this study, we explored correlations between structural covariance networks (SCNs) and cognitive impairment in Parkinson’s disease patients. 101 PD patients and 58 age- and sex-matched healthy controls were enrolled in the study. For each participant, comprehensive neuropsychological testing using the Wechsler Adult Intelligence Scale-III and Cognitive Ability Screening Instrument were conducted. Structural brain MR images were acquired using a 3.0T whole body GE Signa MRI system. T1 structural images were preprocessed and analyzed using Statistical Parametric Mapping software (SPM12) running on Matlab R2016a for voxel-based morphometric analysis and SCN analysis. PD patients with normal cognition received follow-up neuropsychological testing at 1-year interval. Cognitive impairment in PD is associated with degeneration of the amygdala/hippocampus SCN. PD patients with dementia exhibited increased covariance over the prefrontal cortex compared to PD patients with normal cognition (PDN). PDN patients who had developed cognitive impairment at follow-up exhibited decreased gray matter volume of the amygdala/hippocampus SCN in the initial MRI. Our results support a neural network-based mechanism for cognitive impairment in PD patients. SCN analysis may reveal vulnerable networks that can be used to early predict cognitive decline in PD patients.https://doi.org/10.1038/s41598-020-79403-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yueh-Sheng Chen Hsiu-Ling Chen Cheng-Hsien Lu Chih-Ying Lee Kun-Hsien Chou Meng-Hsiang Chen Chiun-Chieh Yu Yun-Ru Lai Pi-Ling Chiang Wei-Che Lin |
spellingShingle |
Yueh-Sheng Chen Hsiu-Ling Chen Cheng-Hsien Lu Chih-Ying Lee Kun-Hsien Chou Meng-Hsiang Chen Chiun-Chieh Yu Yun-Ru Lai Pi-Ling Chiang Wei-Che Lin The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease Scientific Reports |
author_facet |
Yueh-Sheng Chen Hsiu-Ling Chen Cheng-Hsien Lu Chih-Ying Lee Kun-Hsien Chou Meng-Hsiang Chen Chiun-Chieh Yu Yun-Ru Lai Pi-Ling Chiang Wei-Che Lin |
author_sort |
Yueh-Sheng Chen |
title |
The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease |
title_short |
The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease |
title_full |
The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease |
title_fullStr |
The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease |
title_full_unstemmed |
The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease |
title_sort |
corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in parkinson's disease |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-01-01 |
description |
Abstract Structural covariance assesses similarities in gray matter between brain regions and can be applied to study networks of the brain. In this study, we explored correlations between structural covariance networks (SCNs) and cognitive impairment in Parkinson’s disease patients. 101 PD patients and 58 age- and sex-matched healthy controls were enrolled in the study. For each participant, comprehensive neuropsychological testing using the Wechsler Adult Intelligence Scale-III and Cognitive Ability Screening Instrument were conducted. Structural brain MR images were acquired using a 3.0T whole body GE Signa MRI system. T1 structural images were preprocessed and analyzed using Statistical Parametric Mapping software (SPM12) running on Matlab R2016a for voxel-based morphometric analysis and SCN analysis. PD patients with normal cognition received follow-up neuropsychological testing at 1-year interval. Cognitive impairment in PD is associated with degeneration of the amygdala/hippocampus SCN. PD patients with dementia exhibited increased covariance over the prefrontal cortex compared to PD patients with normal cognition (PDN). PDN patients who had developed cognitive impairment at follow-up exhibited decreased gray matter volume of the amygdala/hippocampus SCN in the initial MRI. Our results support a neural network-based mechanism for cognitive impairment in PD patients. SCN analysis may reveal vulnerable networks that can be used to early predict cognitive decline in PD patients. |
url |
https://doi.org/10.1038/s41598-020-79403-x |
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