Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats
Background: Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. Objective: To show that supraorbital stimulation is effective in preclinical models. Metho...
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doaj-7d25b1b858e247d48568a4eb09b3b5e42021-03-18T04:37:10ZengElsevierBrain Stimulation1935-861X2014-03-0172301303Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in RatsTatiana Bregman0Mustansir Diwan1José N. Nobrega2Clement Hamani3Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, CanadaNeuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, CanadaNeuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, CanadaNeuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada; Division of Neurosurgery, University of Toronto, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; Corresponding author. Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada. Tel.: +1 416 6035771.Background: Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. Objective: To show that supraorbital stimulation is effective in preclinical models. Methods: Rats were given supraorbital stimulation at different settings in the forced swim test (FST) and open field. Results: Supraorbital stimulation did not induce an antidepressant-like response in rats undergoing the FST. This is in contrast to other neuromodulation treatments, such as deep brain stimulation, vagus nerve stimulation and electroconvulsive therapy, which are all effective in this paradigm. Conclusions: Supraorbital stimulation was ineffective in rats undergoing the FST. Such findings do not invalidate results of recent clinical trials.http://www.sciencedirect.com/science/article/pii/S1935861X13003483Supraorbital nerveTrigeminal nerveStimulationDepressionRats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tatiana Bregman Mustansir Diwan José N. Nobrega Clement Hamani |
spellingShingle |
Tatiana Bregman Mustansir Diwan José N. Nobrega Clement Hamani Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats Brain Stimulation Supraorbital nerve Trigeminal nerve Stimulation Depression Rats |
author_facet |
Tatiana Bregman Mustansir Diwan José N. Nobrega Clement Hamani |
author_sort |
Tatiana Bregman |
title |
Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
title_short |
Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
title_full |
Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
title_fullStr |
Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
title_full_unstemmed |
Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
title_sort |
supraorbital stimulation does not induce an antidepressant-like response in rats |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2014-03-01 |
description |
Background: Neuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve. Objective: To show that supraorbital stimulation is effective in preclinical models. Methods: Rats were given supraorbital stimulation at different settings in the forced swim test (FST) and open field. Results: Supraorbital stimulation did not induce an antidepressant-like response in rats undergoing the FST. This is in contrast to other neuromodulation treatments, such as deep brain stimulation, vagus nerve stimulation and electroconvulsive therapy, which are all effective in this paradigm. Conclusions: Supraorbital stimulation was ineffective in rats undergoing the FST. Such findings do not invalidate results of recent clinical trials. |
topic |
Supraorbital nerve Trigeminal nerve Stimulation Depression Rats |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X13003483 |
work_keys_str_mv |
AT tatianabregman supraorbitalstimulationdoesnotinduceanantidepressantlikeresponseinrats AT mustansirdiwan supraorbitalstimulationdoesnotinduceanantidepressantlikeresponseinrats AT josennobrega supraorbitalstimulationdoesnotinduceanantidepressantlikeresponseinrats AT clementhamani supraorbitalstimulationdoesnotinduceanantidepressantlikeresponseinrats |
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