Glioma Cells With Genetically Engineered IGF-I Receptor Downregulation Can Persist in the Brain in a Dormant State

Glioma Cells With Genetically Engineered IGF-I Receptor Downregulation Can Persist in the Brain in a Dormant State

Glioblastoma multiforme is an aggressive malignancy, resistant to standard treatment modalities and associated with poor prognosis. We analyzed the role of the IGF system in intracerebral glioma growth using human and rat glioma cells. The glioma cells C6 and U87MG were transduced with a genetically...

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Bibliographic Details
Main Authors: Amir A. Samani, Josephine Nalbantoglu, Pnina Brodt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
glioma
gene therapy
IGF
dormancy
signaling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.555945/full

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