Fibrane the reduced derivative of fenofibrate

Synthetic routes for the preparation of (i) isopropyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methyl propanoate (Reduced Fenofibrate, Fibrane) (2) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate) (1) in a single step is established in good yield and purity under mild conditions...

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Main Authors:	Amanda E. Kotheimer, Wahajul Haq, Ganesaratnam K. Balendiran
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Series:	Results in Chemistry
Subjects:	Fibrate Fibrane
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715619300189

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spelling	doaj-7d4597b71d7e48a8bfb5217e13c5484c2020-12-29T04:14:07ZengElsevierResults in Chemistry2211-71562020-01-012100018Fibrane the reduced derivative of fenofibrateAmanda E. Kotheimer0Wahajul Haq1Ganesaratnam K. Balendiran2Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USADepartment of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USACorresponding author.; Department of Chemistry, Youngstown State University, One University Plaza, Youngstown, OH, USASynthetic routes for the preparation of (i) isopropyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methyl propanoate (Reduced Fenofibrate, Fibrane) (2) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate) (1) in a single step is established in good yield and purity under mild conditions. The newly synthesized derivative of Fenofibrate has been characterized by NMR and IR spectroscopy techniques. Selective conversion of biphenyl ketone moiety, in the presence of ester carbonyl group in Fenofibrate to its corresponding alkane can be performed by Pd catalyst reduction with hydrogen transfer agent ammonium formate.http://www.sciencedirect.com/science/article/pii/S2211715619300189FibrateFibrane
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amanda E. Kotheimer Wahajul Haq Ganesaratnam K. Balendiran
spellingShingle	Amanda E. Kotheimer Wahajul Haq Ganesaratnam K. Balendiran Fibrane the reduced derivative of fenofibrate Results in Chemistry Fibrate Fibrane
author_facet	Amanda E. Kotheimer Wahajul Haq Ganesaratnam K. Balendiran
author_sort	Amanda E. Kotheimer
title	Fibrane the reduced derivative of fenofibrate
title_short	Fibrane the reduced derivative of fenofibrate
title_full	Fibrane the reduced derivative of fenofibrate
title_fullStr	Fibrane the reduced derivative of fenofibrate
title_full_unstemmed	Fibrane the reduced derivative of fenofibrate
title_sort	fibrane the reduced derivative of fenofibrate
publisher	Elsevier
series	Results in Chemistry
issn	2211-7156
publishDate	2020-01-01
description	Synthetic routes for the preparation of (i) isopropyl 2-(4-(4-chlorobenzyl)phenoxy)-2-methyl propanoate (Reduced Fenofibrate, Fibrane) (2) from isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate (Fenofibrate) (1) in a single step is established in good yield and purity under mild conditions. The newly synthesized derivative of Fenofibrate has been characterized by NMR and IR spectroscopy techniques. Selective conversion of biphenyl ketone moiety, in the presence of ester carbonyl group in Fenofibrate to its corresponding alkane can be performed by Pd catalyst reduction with hydrogen transfer agent ammonium formate.
topic	Fibrate Fibrane
url	http://www.sciencedirect.com/science/article/pii/S2211715619300189
work_keys_str_mv	AT amandaekotheimer fibranethereducedderivativeoffenofibrate AT wahajulhaq fibranethereducedderivativeoffenofibrate AT ganesaratnamkbalendiran fibranethereducedderivativeoffenofibrate
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Fibrane the reduced derivative of fenofibrate

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