Longitudinal changes in white matter microstructure after heavy cannabis use
Diffusion tensor imaging (DTI) studies of cannabis users report alterations in brain white matter microstructure, primarily based on cross-sectional research, and etiology of the alterations remains unclear. We report findings from longitudinal voxelwise analyses of DTI data collected at baseline an...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-12-01
|
Series: | Developmental Cognitive Neuroscience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315000948 |
id |
doaj-7d4cb36c38524c53902e117cc0329b37 |
---|---|
record_format |
Article |
spelling |
doaj-7d4cb36c38524c53902e117cc0329b372020-11-24T23:25:38ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072015-12-0116C233510.1016/j.dcn.2015.10.004Longitudinal changes in white matter microstructure after heavy cannabis useMary P. Becker0Paul F. Collins1Kelvin O. Lim2R.L. Muetzel3M. Luciana4Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United StatesDepartment of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United StatesDepartment of Psychiatry, University of Minnesota, 2450 Riverside Avenue South, Minneapolis, MN 55454, United StatesDepartment of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United StatesDepartment of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United StatesDiffusion tensor imaging (DTI) studies of cannabis users report alterations in brain white matter microstructure, primarily based on cross-sectional research, and etiology of the alterations remains unclear. We report findings from longitudinal voxelwise analyses of DTI data collected at baseline and at a 2-year follow-up on 23 young adult (18–20 years old at baseline) regular cannabis users and 23 age-, sex-, and IQ-matched non-using controls with limited substance use histories. Onset of cannabis use was prior to age 17. Cannabis users displayed reduced longitudinal growth in fractional anisotropy in the central and parietal regions of the right and left superior longitudinal fasciculus, in white matter adjacent to the left superior frontal gyrus, in the left corticospinal tract, and in the right anterior thalamic radiation lateral to the genu of the corpus callosum, along with less longitudinal reduction of radial diffusion in the right central/posterior superior longitudinal fasciculus, corticospinal tract, and posterior cingulum. Greater amounts of cannabis use were correlated with reduced longitudinal growth in FA as was relatively impaired performance on a measure of verbal learning. These findings suggest that continued heavy cannabis use during adolescence and young adulthood alters ongoing development of white matter microstructure, contributing to functional impairment.http://www.sciencedirect.com/science/article/pii/S1878929315000948DTICannabisLongitudinalYoung adultWhite matter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mary P. Becker Paul F. Collins Kelvin O. Lim R.L. Muetzel M. Luciana |
spellingShingle |
Mary P. Becker Paul F. Collins Kelvin O. Lim R.L. Muetzel M. Luciana Longitudinal changes in white matter microstructure after heavy cannabis use Developmental Cognitive Neuroscience DTI Cannabis Longitudinal Young adult White matter |
author_facet |
Mary P. Becker Paul F. Collins Kelvin O. Lim R.L. Muetzel M. Luciana |
author_sort |
Mary P. Becker |
title |
Longitudinal changes in white matter microstructure after heavy cannabis use |
title_short |
Longitudinal changes in white matter microstructure after heavy cannabis use |
title_full |
Longitudinal changes in white matter microstructure after heavy cannabis use |
title_fullStr |
Longitudinal changes in white matter microstructure after heavy cannabis use |
title_full_unstemmed |
Longitudinal changes in white matter microstructure after heavy cannabis use |
title_sort |
longitudinal changes in white matter microstructure after heavy cannabis use |
publisher |
Elsevier |
series |
Developmental Cognitive Neuroscience |
issn |
1878-9293 1878-9307 |
publishDate |
2015-12-01 |
description |
Diffusion tensor imaging (DTI) studies of cannabis users report alterations in brain white matter microstructure, primarily based on cross-sectional research, and etiology of the alterations remains unclear. We report findings from longitudinal voxelwise analyses of DTI data collected at baseline and at a 2-year follow-up on 23 young adult (18–20 years old at baseline) regular cannabis users and 23 age-, sex-, and IQ-matched non-using controls with limited substance use histories. Onset of cannabis use was prior to age 17. Cannabis users displayed reduced longitudinal growth in fractional anisotropy in the central and parietal regions of the right and left superior longitudinal fasciculus, in white matter adjacent to the left superior frontal gyrus, in the left corticospinal tract, and in the right anterior thalamic radiation lateral to the genu of the corpus callosum, along with less longitudinal reduction of radial diffusion in the right central/posterior superior longitudinal fasciculus, corticospinal tract, and posterior cingulum. Greater amounts of cannabis use were correlated with reduced longitudinal growth in FA as was relatively impaired performance on a measure of verbal learning. These findings suggest that continued heavy cannabis use during adolescence and young adulthood alters ongoing development of white matter microstructure, contributing to functional impairment. |
topic |
DTI Cannabis Longitudinal Young adult White matter |
url |
http://www.sciencedirect.com/science/article/pii/S1878929315000948 |
work_keys_str_mv |
AT marypbecker longitudinalchangesinwhitemattermicrostructureafterheavycannabisuse AT paulfcollins longitudinalchangesinwhitemattermicrostructureafterheavycannabisuse AT kelvinolim longitudinalchangesinwhitemattermicrostructureafterheavycannabisuse AT rlmuetzel longitudinalchangesinwhitemattermicrostructureafterheavycannabisuse AT mluciana longitudinalchangesinwhitemattermicrostructureafterheavycannabisuse |
_version_ |
1725556463663841280 |