Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma
Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammatio...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Limited liability company «Science and Innovations» (Saratov)
2020-03-01
|
Series: | Russian Open Medical Journal |
Subjects: | |
Online Access: | http://www.romj.org/node/306 |
id |
doaj-7d5a608450be4ed39754535f161881be |
---|---|
record_format |
Article |
spelling |
doaj-7d5a608450be4ed39754535f161881be2021-10-06T12:15:47ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152020-03-0191e010210.15275/rusomj.2020.0102Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthmaOxana Y. KytikovaTatyana P. NovgorodtsevaYulia K. DenisenkoMarina V. AntonyukTatyana A. GvozdenkoAsthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammation, bronchial hyperreactivity and respiratory symptoms of asthma such as bronchospasm and cough. TRP channels are expressed in the respiratory tract. Their activation is mediated by endogenous and exogenous factors involved in the pathogenesis of asthma. The study of functioning and regulation of TRP channels is relevant, as they could be important therapeutic targets for asthma. The aim of the review is to summarize modern ideas about the mechanisms of functioning and regulation of members of the TRP channel superfamily, the role of which in lung pathology and physiology are the best studied.http://www.romj.org/node/306asthmatransient receptor potential ion channels |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oxana Y. Kytikova Tatyana P. Novgorodtseva Yulia K. Denisenko Marina V. Antonyuk Tatyana A. Gvozdenko |
spellingShingle |
Oxana Y. Kytikova Tatyana P. Novgorodtseva Yulia K. Denisenko Marina V. Antonyuk Tatyana A. Gvozdenko Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma Russian Open Medical Journal asthma transient receptor potential ion channels |
author_facet |
Oxana Y. Kytikova Tatyana P. Novgorodtseva Yulia K. Denisenko Marina V. Antonyuk Tatyana A. Gvozdenko |
author_sort |
Oxana Y. Kytikova |
title |
Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
title_short |
Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
title_full |
Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
title_fullStr |
Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
title_full_unstemmed |
Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
title_sort |
dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma |
publisher |
Limited liability company «Science and Innovations» (Saratov) |
series |
Russian Open Medical Journal |
issn |
2304-3415 |
publishDate |
2020-03-01 |
description |
Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammation, bronchial hyperreactivity and respiratory symptoms of asthma such as bronchospasm and cough. TRP channels are expressed in the respiratory tract. Their activation is mediated by endogenous and exogenous factors involved in the pathogenesis of asthma. The study of functioning and regulation of TRP channels is relevant, as they could be important therapeutic targets for asthma. The aim of the review is to summarize modern ideas about the mechanisms of functioning and regulation of members of the TRP channel superfamily, the role of which in lung pathology and physiology are the best studied. |
topic |
asthma transient receptor potential ion channels |
url |
http://www.romj.org/node/306 |
work_keys_str_mv |
AT oxanaykytikova dysfunctionoftransientreceptorpotentialionchannelsasanimportantpathophysiologicalmechanisminasthma AT tatyanapnovgorodtseva dysfunctionoftransientreceptorpotentialionchannelsasanimportantpathophysiologicalmechanisminasthma AT yuliakdenisenko dysfunctionoftransientreceptorpotentialionchannelsasanimportantpathophysiologicalmechanisminasthma AT marinavantonyuk dysfunctionoftransientreceptorpotentialionchannelsasanimportantpathophysiologicalmechanisminasthma AT tatyanaagvozdenko dysfunctionoftransientreceptorpotentialionchannelsasanimportantpathophysiologicalmechanisminasthma |
_version_ |
1716840855745069056 |