ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alp...
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doaj-7d66be9c4fbe4fb6a63cbb2502e4c4722020-11-25T02:31:00ZengMDPI AGNutrients2072-66432020-09-01122751275110.3390/nu12092751ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and CancerStefania D’Angelo0Maria Letizia Motti1Rosaria Meccariello2Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, ItalyDipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, ItalyDipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, via Medina 40, 80133 Napoli, ItalyRecently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food–related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic.https://www.mdpi.com/2072-6643/12/9/2751obesityω-3PUFAsω-6PUFAsendocannabinoidsCRCfatty acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefania D’Angelo Maria Letizia Motti Rosaria Meccariello |
spellingShingle |
Stefania D’Angelo Maria Letizia Motti Rosaria Meccariello ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer Nutrients obesity ω-3PUFAs ω-6PUFAs endocannabinoids CRC fatty acids |
author_facet |
Stefania D’Angelo Maria Letizia Motti Rosaria Meccariello |
author_sort |
Stefania D’Angelo |
title |
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer |
title_short |
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer |
title_full |
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer |
title_fullStr |
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer |
title_full_unstemmed |
ω-3 and ω-6 Polyunsaturated Fatty Acids, Obesity and Cancer |
title_sort |
ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-09-01 |
description |
Recently, nutraceutical bioactive compounds in foods have been discovered for their potential health benefits regarding the prevention of chronic disorders, such as cancer, and inflammatory, cardiovascular, and metabolic diseases. Dietary omega-3 polyunsaturated fatty acids (ω-3PUFAs), including alpha-linolenic acid, docosapentaenoic acid, and eicosapentaenoic acid, are mostly attractive. They are available for the customers worldwide from commonly used foods and/or as components of commercial food supplements. The anti-inflammatory and hypotriglyceridemic effects of these fatty acids are well known, whereas pro-inflammatory properties have been recognized in their dietary counterparts, the ω-6PUFAs. Both ω-3 and ω-6PUFAs contribute to the production of lipid mediators such as endocannabinoids that are notably involved in control of food intake, energy sensing, and food–related disorders. In this review, we present ω-3 and ω-6PUFAs and their derivatives, endocannabinoids; discuss the anti-obesity effects of ω-3PUFAs; their roles in inflammation and colorectal cancer development; and how their action can be co-preventative and co-therapeutic. |
topic |
obesity ω-3PUFAs ω-6PUFAs endocannabinoids CRC fatty acids |
url |
https://www.mdpi.com/2072-6643/12/9/2751 |
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