Peculiarities of Hemiplegic Migraine in Children

The article describes the individual peculiarities of a rare disease — hemiplegic migraine — in 3 patients (two girls aged 2 and 14 years old and a boy of 16 years). In common clinical aspect there was a correlation between the migraine-attack and the slight head trauma in all patients. Attack sympt...

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Main Authors: S. L. Moiseeva, C. Betzler, T. Herberholdt, G. Kluger, M. Staudt
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2016-01-01
Series:Voprosy Sovremennoj Pediatrii
Subjects:
mri
Online Access:https://vsp.spr-journal.ru/jour/article/view/1565
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spelling doaj-7d6973994f624efe9512808484d7f5ac2021-07-28T21:15:43Zeng"Paediatrician" Publishers LLC Voprosy Sovremennoj Pediatrii1682-55271682-55352016-01-0114673273410.15690/vsp.v14i6.14841556Peculiarities of Hemiplegic Migraine in ChildrenS. L. Moiseeva0C. Betzler1T. Herberholdt2G. Kluger3M. Staudt4Schoen-Klinik Vogtareuth, Neuropadiatrie, Deutschland (Germany)Schoen-Klinik Vogtareuth, Neuropadiatrie, Deutschland (Germany)Schoen-Klinik Vogtareuth, Neuropadiatrie, Deutschland (Germany)Schoen-Klinik Vogtareuth, Neuropadiatrie, Deutschland (Germany)Schoen-Klinik Vogtareuth, Neuropadiatrie, Deutschland (Germany)The article describes the individual peculiarities of a rare disease — hemiplegic migraine — in 3 patients (two girls aged 2 and 14 years old and a boy of 16 years). In common clinical aspect there was a correlation between the migraine-attack and the slight head trauma in all patients. Attack symptoms were almost identical: hemiparesis, aphasia, ataxia. The family history for migraine was burdened in both girls. A genetic testing in the boy and in the smallest girl demonstrated CACNA1A gene mutation, in the teen girl — ATP1A2 gene mutation. The electroencephalograms in all patients during the acute phase presented signs of hemipcortical brain dysfunction. The magnetic resonance imaging revealed prominent but reversible hemicortical oedema. The repeated MRI studies diagnosed nonrelevant for this disease hemicortical atrophy (girl 2 years) and atrophy of the cerebellum (the boy). Due to the rarity of the disease so far there are no clear guidelines for its treatment and prevention. In view of the pathogenesis for the prevention patients were prescribed medications changing the activity of cytoplasmic calcium and sodium canals.https://vsp.spr-journal.ru/jour/article/view/1565childrenhemiplegic migrainemricacna1aatp1a2
collection DOAJ
language English
format Article
sources DOAJ
author S. L. Moiseeva
C. Betzler
T. Herberholdt
G. Kluger
M. Staudt
spellingShingle S. L. Moiseeva
C. Betzler
T. Herberholdt
G. Kluger
M. Staudt
Peculiarities of Hemiplegic Migraine in Children
Voprosy Sovremennoj Pediatrii
children
hemiplegic migraine
mri
cacna1a
atp1a2
author_facet S. L. Moiseeva
C. Betzler
T. Herberholdt
G. Kluger
M. Staudt
author_sort S. L. Moiseeva
title Peculiarities of Hemiplegic Migraine in Children
title_short Peculiarities of Hemiplegic Migraine in Children
title_full Peculiarities of Hemiplegic Migraine in Children
title_fullStr Peculiarities of Hemiplegic Migraine in Children
title_full_unstemmed Peculiarities of Hemiplegic Migraine in Children
title_sort peculiarities of hemiplegic migraine in children
publisher "Paediatrician" Publishers LLC
series Voprosy Sovremennoj Pediatrii
issn 1682-5527
1682-5535
publishDate 2016-01-01
description The article describes the individual peculiarities of a rare disease — hemiplegic migraine — in 3 patients (two girls aged 2 and 14 years old and a boy of 16 years). In common clinical aspect there was a correlation between the migraine-attack and the slight head trauma in all patients. Attack symptoms were almost identical: hemiparesis, aphasia, ataxia. The family history for migraine was burdened in both girls. A genetic testing in the boy and in the smallest girl demonstrated CACNA1A gene mutation, in the teen girl — ATP1A2 gene mutation. The electroencephalograms in all patients during the acute phase presented signs of hemipcortical brain dysfunction. The magnetic resonance imaging revealed prominent but reversible hemicortical oedema. The repeated MRI studies diagnosed nonrelevant for this disease hemicortical atrophy (girl 2 years) and atrophy of the cerebellum (the boy). Due to the rarity of the disease so far there are no clear guidelines for its treatment and prevention. In view of the pathogenesis for the prevention patients were prescribed medications changing the activity of cytoplasmic calcium and sodium canals.
topic children
hemiplegic migraine
mri
cacna1a
atp1a2
url https://vsp.spr-journal.ru/jour/article/view/1565
work_keys_str_mv AT slmoiseeva peculiaritiesofhemiplegicmigraineinchildren
AT cbetzler peculiaritiesofhemiplegicmigraineinchildren
AT therberholdt peculiaritiesofhemiplegicmigraineinchildren
AT gkluger peculiaritiesofhemiplegicmigraineinchildren
AT mstaudt peculiaritiesofhemiplegicmigraineinchildren
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