Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks
Neuronal networks in the brain are the structural basis of human cognitive function, and the plasticity of neuronal networks is thought to be the principal neural mechanism underlying learning and memory. Dominated by the Hebbian theory, researchers have devoted extensive effort to studying the chan...
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doaj-7d70f527f0514851ac60279b5c7bb9082020-11-24T22:57:27ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882018-11-011210.3389/fncom.2018.00091424829Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal NetworksYe Yuan0Ye Yuan1Hong Huo2Hong Huo3Peng Zhao4Peng Zhao5Jian Liu6Jian Liu7Jiaxing Liu8Jiaxing Liu9Fu Xing10Fu Xing11Tao Fang12Tao Fang13Department of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education, Shanghai, ChinaNeuronal networks in the brain are the structural basis of human cognitive function, and the plasticity of neuronal networks is thought to be the principal neural mechanism underlying learning and memory. Dominated by the Hebbian theory, researchers have devoted extensive effort to studying the changes in synaptic connections between neurons. However, understanding the network topology of all synaptic connections has been neglected over the past decades. Furthermore, increasing studies indicate that synaptic activities are tightly coupled with metabolic energy, and metabolic energy is a unifying principle governing neuronal activities. Therefore, the network topology of all synaptic connections may also be governed by metabolic energy. Here, by implementing a computational model, we investigate the general synaptic organization rules for neurons and neuronal networks from the perspective of energy metabolism. We find that to maintain the energy balance of individual neurons in the proposed model, the number of synaptic connections is inversely proportional to the average of the synaptic weights. This strategy may be adopted by neurons to ensure that the ability of neurons to transmit signals matches their own energy metabolism. In addition, we find that the density of neuronal networks is also an important factor in the energy balance of neuronal networks. An abnormal increase or decrease in the network density could lead to failure of energy metabolism in the neuronal network. These rules may change our view of neuronal networks in the brain and have guiding significance for the design of neuronal network models.https://www.frontiersin.org/article/10.3389/fncom.2018.00091/fullneuronal networksnetwork topologysynaptic organization rulesmetabolic energyenergy balancecomputational model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ye Yuan Ye Yuan Hong Huo Hong Huo Peng Zhao Peng Zhao Jian Liu Jian Liu Jiaxing Liu Jiaxing Liu Fu Xing Fu Xing Tao Fang Tao Fang |
spellingShingle |
Ye Yuan Ye Yuan Hong Huo Hong Huo Peng Zhao Peng Zhao Jian Liu Jian Liu Jiaxing Liu Jiaxing Liu Fu Xing Fu Xing Tao Fang Tao Fang Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks Frontiers in Computational Neuroscience neuronal networks network topology synaptic organization rules metabolic energy energy balance computational model |
author_facet |
Ye Yuan Ye Yuan Hong Huo Hong Huo Peng Zhao Peng Zhao Jian Liu Jian Liu Jiaxing Liu Jiaxing Liu Fu Xing Fu Xing Tao Fang Tao Fang |
author_sort |
Ye Yuan |
title |
Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks |
title_short |
Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks |
title_full |
Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks |
title_fullStr |
Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks |
title_full_unstemmed |
Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks |
title_sort |
constraints of metabolic energy on the number of synaptic connections of neurons and the density of neuronal networks |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Computational Neuroscience |
issn |
1662-5188 |
publishDate |
2018-11-01 |
description |
Neuronal networks in the brain are the structural basis of human cognitive function, and the plasticity of neuronal networks is thought to be the principal neural mechanism underlying learning and memory. Dominated by the Hebbian theory, researchers have devoted extensive effort to studying the changes in synaptic connections between neurons. However, understanding the network topology of all synaptic connections has been neglected over the past decades. Furthermore, increasing studies indicate that synaptic activities are tightly coupled with metabolic energy, and metabolic energy is a unifying principle governing neuronal activities. Therefore, the network topology of all synaptic connections may also be governed by metabolic energy. Here, by implementing a computational model, we investigate the general synaptic organization rules for neurons and neuronal networks from the perspective of energy metabolism. We find that to maintain the energy balance of individual neurons in the proposed model, the number of synaptic connections is inversely proportional to the average of the synaptic weights. This strategy may be adopted by neurons to ensure that the ability of neurons to transmit signals matches their own energy metabolism. In addition, we find that the density of neuronal networks is also an important factor in the energy balance of neuronal networks. An abnormal increase or decrease in the network density could lead to failure of energy metabolism in the neuronal network. These rules may change our view of neuronal networks in the brain and have guiding significance for the design of neuronal network models. |
topic |
neuronal networks network topology synaptic organization rules metabolic energy energy balance computational model |
url |
https://www.frontiersin.org/article/10.3389/fncom.2018.00091/full |
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