Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology
Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk s...
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Cell Physiol Biochem Press GmbH & Co KG
2015-12-01
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doaj-7d7275b591984c2490f32d11f84b1e9e2020-11-25T03:32:26ZengCell Physiol Biochem Press GmbH & Co KGNeurosignals1424-862X1424-86382015-12-01231718310.1159/000442605442605Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent PsychopathologyAndré SchmidtClaudia LenzRenata SmieskovaFabienne HarrisbergerAnna WalterAnita Riecher-RösslerAndor SimonUndine E. LangPhilip McGuirePaolo Fusar-PoliStefan J. BorgwardtBackground/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk samples and findings in both groups are inconsistent, in particular along the superior longitudinal fasciculus (SLF). Methods: This DTI study used tract-based spatial statistics (TBSS) to compare fractional anisotropy (FA) and mean diffusivity (MD) between ARMS subjects, untreated and antipsychotic-treated FEP patients and healthy controls (HC) across the whole brain and the SLF. Results: Compared to HC, ARMS and FEP patients showed increased FA and decreased MD in diverse regions across the whole brain including the SLF. FA in the SLF was positively correlated with positive psychotic symptoms in ARMS and FEP individuals. Furthermore, untreated but not treated FEP patients showed increased FA in the left inferior longitudinal fasciculus and right SLF. Conclusion: This study revealed increased FA and decreased MD in early stages of psychosis in widespread white matter tracts including the SLF. Our findings further suggest that microstructural changes in the SLF are probably related to state-dependent psychopathology.http://www.karger.com/Article/FullText/442605DTIFractional anisotropyTBSSHigh-riskFirst-episode psychosisPsychosisPsychopathologyMean diffusivityAntipsychotics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
André Schmidt Claudia Lenz Renata Smieskova Fabienne Harrisberger Anna Walter Anita Riecher-Rössler Andor Simon Undine E. Lang Philip McGuire Paolo Fusar-Poli Stefan J. Borgwardt |
spellingShingle |
André Schmidt Claudia Lenz Renata Smieskova Fabienne Harrisberger Anna Walter Anita Riecher-Rössler Andor Simon Undine E. Lang Philip McGuire Paolo Fusar-Poli Stefan J. Borgwardt Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology Neurosignals DTI Fractional anisotropy TBSS High-risk First-episode psychosis Psychosis Psychopathology Mean diffusivity Antipsychotics |
author_facet |
André Schmidt Claudia Lenz Renata Smieskova Fabienne Harrisberger Anna Walter Anita Riecher-Rössler Andor Simon Undine E. Lang Philip McGuire Paolo Fusar-Poli Stefan J. Borgwardt |
author_sort |
André Schmidt |
title |
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology |
title_short |
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology |
title_full |
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology |
title_fullStr |
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology |
title_full_unstemmed |
Brain Diffusion Changes in Emerging Psychosis and the Impact of State-Dependent Psychopathology |
title_sort |
brain diffusion changes in emerging psychosis and the impact of state-dependent psychopathology |
publisher |
Cell Physiol Biochem Press GmbH & Co KG |
series |
Neurosignals |
issn |
1424-862X 1424-8638 |
publishDate |
2015-12-01 |
description |
Background/Aims: Previous diffusion tensor imaging (DTI) studies have shown microstructural changes in the brain white matter of at-risk mental state (ARMS) subjects for psychosis and patients with first-episode psychosis (FEP). However, only a few studies have been conducted in clinical high-risk samples and findings in both groups are inconsistent, in particular along the superior longitudinal fasciculus (SLF). Methods: This DTI study used tract-based spatial statistics (TBSS) to compare fractional anisotropy (FA) and mean diffusivity (MD) between ARMS subjects, untreated and antipsychotic-treated FEP patients and healthy controls (HC) across the whole brain and the SLF. Results: Compared to HC, ARMS and FEP patients showed increased FA and decreased MD in diverse regions across the whole brain including the SLF. FA in the SLF was positively correlated with positive psychotic symptoms in ARMS and FEP individuals. Furthermore, untreated but not treated FEP patients showed increased FA in the left inferior longitudinal fasciculus and right SLF. Conclusion: This study revealed increased FA and decreased MD in early stages of psychosis in widespread white matter tracts including the SLF. Our findings further suggest that microstructural changes in the SLF are probably related to state-dependent psychopathology. |
topic |
DTI Fractional anisotropy TBSS High-risk First-episode psychosis Psychosis Psychopathology Mean diffusivity Antipsychotics |
url |
http://www.karger.com/Article/FullText/442605 |
work_keys_str_mv |
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