Monitoring of clozapine and norclozapine concentrations in schizophrenia treatment

• Main Authors: N. V. Baymeeva, L. M. Krasnykh, I. I. Miroshnichenko
• Format: Article
• Language: Russian
• Published: OOO “Vashe Tsifrovoe Izdatelstvo” 2018-02-01
• Series: Ведомости Научного центра экспертизы средств медицинского применения
• Subjects: терапевтический лекарственный мониторинг; шизофрения; тандемная хроматомасс-спектрометрия; клозапин; норклозапин; tdm; schizophrenia; liquid chromatography tandem-mass spectrometry; clozapine; norclozapine
• Online Access: https://www.vedomostincesmp.ru/jour/article/view/107
• ISSN: 1991-2919; 2619-1172

The article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the administered drug doses have been studied. Clozapine and norclozapine assay in human blood has been performed by high performance liquid chromatography with mass spectrometric detection. Monitoring and subsequent data analysis has been supported with necessary clinical information in the form of special requests - TDM cards. The obtained data on concentration levels have been arranged as follows: 38.64 % within therapeutic range, 38.64 % within subtherapeutic range (