Phosphatidylserine exposure is required for ADAM17 sheddase function

ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its s...

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Main Authors:	Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi, Karina Reiss
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11523

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spelling	doaj-7d870aa38fd548259ffdc80c22adca2f2021-05-11T10:57:16ZengNature Publishing GroupNature Communications2041-17232016-05-017111410.1038/ncomms11523Phosphatidylserine exposure is required for ADAM17 sheddase functionAnselm Sommer0Felix Kordowski1Joscha Büch2Thorsten Maretzky3Astrid Evers4Jörg Andrä5Stefan Düsterhöft6Matthias Michalek7Inken Lorenzen8Prasath Somasundaram9Andreas Tholey10Frank D. Sönnichsen11Karl Kunzelmann12Lena Heinbockel13Christian Nehls14Thomas Gutsmann15Joachim Grötzinger16Sucharit Bhakdi17Karina Reiss18Department of Dermatology, University of KielDepartment of Dermatology, University of KielDepartment of Dermatology, University of KielArthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell UniversityArthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell UniversityHamburg University of Applied ScienceInstitute of Biochemistry, University of KielInstitute of Biochemistry, University of KielInstitute of Biochemistry, University of KielDivision of Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, University of KielDivision of Systematic Proteome Research and Bioanalytics, Institute for Experimental Medicine, University of KielOtto Diels Institute for Organic Chemistry, University of KielPhysiological Institute, University of RegensburgForschungszentrum Borstel, Leibniz-Zentrum für Medizin and BiowissenschaftenForschungszentrum Borstel, Leibniz-Zentrum für Medizin and BiowissenschaftenForschungszentrum Borstel, Leibniz-Zentrum für Medizin and BiowissenschaftenInstitute of Biochemistry, University of KielDepartment of Dermatology, University of KielDepartment of Dermatology, University of KielADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.https://doi.org/10.1038/ncomms11523
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss
spellingShingle	Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss Phosphatidylserine exposure is required for ADAM17 sheddase function Nature Communications
author_facet	Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss
author_sort	Anselm Sommer
title	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_short	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_full	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_fullStr	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_full_unstemmed	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_sort	phosphatidylserine exposure is required for adam17 sheddase function
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-05-01
description	ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.
url	https://doi.org/10.1038/ncomms11523
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Phosphatidylserine exposure is required for ADAM17 sheddase function

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