Mitochondrial Dysfunction in Neural Injury

Mitochondrial Dysfunction in Neural Injury

Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observe...

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Main Authors: Xiu-Yun Zhao, Mei-Hong Lu, De-Juan Yuan, De-En Xu, Pei-Pei Yao, Wen-Li Ji, Hong Chen, Wen-Long Liu, Chen-Xiao Yan, Yi-Yuan Xia, Shao Li, Jin Tao, Quan-Hong Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neuroscience
Subjects:
mitochondrial dysfunction
neural injury
mitochondria
neurodegeneration
neurological disorders
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00030/full
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record_format Article
collection DOAJ
language English
format Article
sources DOAJ
author Xiu-Yun Zhao
Xiu-Yun Zhao
Mei-Hong Lu
Mei-Hong Lu
De-Juan Yuan
De-Juan Yuan
De-En Xu
Pei-Pei Yao
Pei-Pei Yao
Wen-Li Ji
Wen-Li Ji
Hong Chen
Hong Chen
Wen-Long Liu
Wen-Long Liu
Chen-Xiao Yan
Chen-Xiao Yan
Yi-Yuan Xia
Yi-Yuan Xia
Shao Li
Jin Tao
Jin Tao
Quan-Hong Ma
spellingShingle Xiu-Yun Zhao
Xiu-Yun Zhao
Mei-Hong Lu
Mei-Hong Lu
De-Juan Yuan
De-Juan Yuan
De-En Xu
Pei-Pei Yao
Pei-Pei Yao
Wen-Li Ji
Wen-Li Ji
Hong Chen
Hong Chen
Wen-Long Liu
Wen-Long Liu
Chen-Xiao Yan
Chen-Xiao Yan
Yi-Yuan Xia
Yi-Yuan Xia
Shao Li
Jin Tao
Jin Tao
Quan-Hong Ma
Mitochondrial Dysfunction in Neural Injury
Frontiers in Neuroscience
mitochondrial dysfunction
neural injury
mitochondria
neurodegeneration
neurological disorders
author_facet Xiu-Yun Zhao
Xiu-Yun Zhao
Mei-Hong Lu
Mei-Hong Lu
De-Juan Yuan
De-Juan Yuan
De-En Xu
Pei-Pei Yao
Pei-Pei Yao
Wen-Li Ji
Wen-Li Ji
Hong Chen
Hong Chen
Wen-Long Liu
Wen-Long Liu
Chen-Xiao Yan
Chen-Xiao Yan
Yi-Yuan Xia
Yi-Yuan Xia
Shao Li
Jin Tao
Jin Tao
Quan-Hong Ma
author_sort Xiu-Yun Zhao
title Mitochondrial Dysfunction in Neural Injury
title_short Mitochondrial Dysfunction in Neural Injury
title_full Mitochondrial Dysfunction in Neural Injury
title_fullStr Mitochondrial Dysfunction in Neural Injury
title_full_unstemmed Mitochondrial Dysfunction in Neural Injury
title_sort mitochondrial dysfunction in neural injury
publisher Frontiers Media S.A.
series Frontiers in Neuroscience
issn 1662-453X
publishDate 2019-02-01
description Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.
topic mitochondrial dysfunction
neural injury
mitochondria
neurodegeneration
neurological disorders
url https://www.frontiersin.org/article/10.3389/fnins.2019.00030/full
work_keys_str_mv AT xiuyunzhao mitochondrialdysfunctioninneuralinjury
AT xiuyunzhao mitochondrialdysfunctioninneuralinjury
AT meihonglu mitochondrialdysfunctioninneuralinjury
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AT dejuanyuan mitochondrialdysfunctioninneuralinjury
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AT deenxu mitochondrialdysfunctioninneuralinjury
AT peipeiyao mitochondrialdysfunctioninneuralinjury
AT peipeiyao mitochondrialdysfunctioninneuralinjury
AT wenliji mitochondrialdysfunctioninneuralinjury
AT wenliji mitochondrialdysfunctioninneuralinjury
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AT chenxiaoyan mitochondrialdysfunctioninneuralinjury
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spelling doaj-7d8a18013bfc4381a4478160a94a11f42020-11-25T00:00:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-02-011310.3389/fnins.2019.00030421392Mitochondrial Dysfunction in Neural InjuryXiu-Yun Zhao0Xiu-Yun Zhao1Mei-Hong Lu2Mei-Hong Lu3De-Juan Yuan4De-Juan Yuan5De-En Xu6Pei-Pei Yao7Pei-Pei Yao8Wen-Li Ji9Wen-Li Ji10Hong Chen11Hong Chen12Wen-Long Liu13Wen-Long Liu14Chen-Xiao Yan15Chen-Xiao Yan16Yi-Yuan Xia17Yi-Yuan Xia18Shao Li19Jin Tao20Jin Tao21Quan-Hong Ma22Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, ChinaWuxi No. 2 People’s Hospital, Wuxi, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Physiology, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaDepartment of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou, ChinaInstitute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou, ChinaMitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.https://www.frontiersin.org/article/10.3389/fnins.2019.00030/fullmitochondrial dysfunctionneural injurymitochondrianeurodegenerationneurological disorders

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